Idiopathic thrombocytopenia refractery to therapy of cyclosporine A in clinical practice – case report

Česká verzia

Authors: Lucia Schwarzová; Zdenko Pirník; Natália Štecová
Published in the journal: Čes. slov. Farm., 2017; 66, 233-237
Category: Kazuistika

Summary

Primary immune thrombocytopenia (idiopathic thrombocytopenic purpura; ITP) is an autoimmune disorder characterized by isolated thrombocytopenia without abnormalities in the erythroid and myeloid/lymphoid lineages. The incidence of ITP in adults is estimated at approximately 1.6–3.9 per 100 000 persons/year. The aim of this study was to analyze a case report of a patient with diagnosed immune thrombocytopenia (D69.3) resistant to cyclosporine A therapy as well as an evaluation of factors that could contribute to an inadequate response to cyclosporine A. The results show a multifactorial origin of thrombocytopenia and a possible effect on refractivity to cyclosporine A therapy caused by long-term smoking, MDR-1 gene polymorphism, genetic predisposition to autoimmune diseases, allergic reactions as a manifestation of hypersensitivity in the immune system, controversial compliance of the patient, overcome infections as well as impact of drugs taken.

Key words:
immune thrombocytopenia • refractery form • cyclosporine A • therapy • platelets

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