Serum Anti-Endomysium Antibodies (AEA) in the Diagnostic Algorithm of Coeliac Disease

Česká verzia

Authors: P. Makovický
Authors place of work: Czech University of Life Sciences, Praha
Published in the journal: Epidemiol. Mikrobiol. Imunol. 58, 2009, č. 4, s. 163-166

Summary

The diagnostic relevance of serum anti-endomysium antibodies (AEA) in patients with celiac disease is discussed. A group of 23 newly diagnosed patients, i.e. seven patients with mild AEA positivity (+), nine patients with intermediate AEA positivity (++) and seven patients with strong AEA positivity (+++), was selected. The AEA reactivity was evaluated semiquantitatively. Celiac disease and AEA are less than 100% correlated. The final diagnosis has to be confirmed by histopathology of small intestine biopsy specimens. The available targeted screening is an alternative with a potential for the detection of atypical forms of celiac disease. Another alternative for early diagnosis is the detection of intraepithelial lymphocyte activity or of lymphocyte mediators.

Key words:
apoptosis – gluten-free diet – diagnostics – gluten – malabsorption syndrome – small bowel – tissue transglutaminase – TNF family.

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