Fecal bacteriotherapy in the treatment of Clostridium difficile infection

Česká verzia

Authors: R. Stebel ^1,2; R. Svačinka ^1,2; L. Vojtilová ^1,2; M. Freibergerová ²; P. Husa ^1,2
Authors place of work: Lékařská fakulta Masarykovy Univerzity, Brno ¹; Klinika infekčních chorob, Fakultní nemocnice Brno ²
Published in the journal: Epidemiol. Mikrobiol. Imunol. 67, 2018, č. 3, s. 104-109
Category: Původní práce

Summary

Aim:

Using a prospective analysis to assess the success of faecal bacteriotherapy (FBT) in antibiotic-associated colitis due to Clostridium difficile. To analyse whether any of the factors according to which the treated patients can be categorized has a statistically significant effect on the therapeutic outcome.

Materials and methods:

During the 2-year study period (2015–2016), 71 patients received FBT. After treatment, the patients were followed up by means of clinic visits or by phone. If colitis did not recur within eight weeks of follow-up, the treatment was considered successful.

Results:

The overall success rate was 76%, with statistically insignificant decline in recurrences. Subgroup analysis did not show any statistically significant difference in the success rate between the routes of administration, i.e. through a naso-enteral feeding tube and rectal enema. Likewise, there were no statistically significant differences in the success rate between the types of prior antibiotic therapy or between using fresh and cryo-stored stool suspension. No unexpected adverse event or lethality occurred during the study period.

Conclusions:

Faecal bacteriotherapy is a successful and safe therapeutic alternative for recurrent C. difficile infections.

KEYWORDS:

faecal bacteriotherapy – recurrent Clostridium difficile colitis – intestinal microbiome

Zdroje

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