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Pineal Germ Cell Tumors: Review


Germinatívne nádory pineálnej oblasti: prehľad

Úvod:
Primárne intrakraniálne germinatívne tumory predstavujú zriedkavú skupinu nádorov, ktoré sa vyskytujú v detstve a u mladých dospelých. WHO klasifikácia delí intrakraniálne tumory na germinómy a negerminómy. Najčastejšia lokalita týchto nádorov je pineálna a supraselárna oblasť. Klinické príznaky a symptómy závisia od lokalizácie tumoru, najčastejšie sú to príznaky v dôsledku zvýšeného intrakraniálnho tlaku, Parinaudov syndróm, bitemporálna hemianopsia, príznaky z endokrinného deficitu. Zobrazovacím vyšetrením voľby pri diagnostike intrakraniálnych germinatívnych tumorov je MRI vyšetrenie mozgu s použitím kontrastnej látky gadolinium. Zobrazovacie vyšetrenia však neposkytnú dostatočnú informáciu o type nádoru, k tomu je potrebná bioptizácia. Výnimkou sú prípady s charakteristicky zvýšenými hladinami nádorových markerov (AFP a β-hCG) stanovenými v sére a cerebrospinálnom moku.

Klinický prípad:
U 26-ročného pacienta so zhoršeným zrakom s poruchou zaostriť a svetloplachosťou, výraznou únavou a ospalosťou, nevoľnosťou, občasným zvracaním, s intermitentnými bolesťami hlavy a klinicky prítomným Parinaudovým syndróm sa zistil germinatívny nádor pineálnej oblasti. Zrealizované MR vyšetrenie mozgu ukázalo tumoróznu expanziu v pineálnej oblasti a v pravej časti mezencefala. Bola vykonaná radikálna exstirpácia tumoru v pineálnej oblasti. Pri kontrolnom MR vyšetrení mozgu sa zistila recidíva ochorenia. Pacient absolvoval kraniospinálne ožiarenie s následnou pooperačnou chemoterapiou (schéma cisplatina a etoposid), celkovo tri cykly. V súčasnej dobe je pacient 30 mesiacov po ukončení úspešnej onkologickej liečby v klinickej remisii ochorenia.

Záver:
Liečba a prognóza tohto nádorového ochorenia je rozdielna v jednotlivých skupinách. Germinómy majú lepšie prežívanie než negerminómy. 5-ročné prežívanie germinómov po aplikácii samotnej rádioterapie bolo > 90 %. Pridanie chemoterapie viedlo k zníženiu dávky a zmenšeniu ožarovanej oblasti, s dosiahnutím menších nežiadúcich účinkov a bez zníženia kurability. Negerminómy sú menej rádiosenzitívne než germinómy, ale použitím adjuvantnej chemoterapie sa dosiahlo zlepšenie prežívania. Naďalej však menežment týchto nádorov ostáva kontroverzný.

Kľúčové slová:
pinealóm – germinóm – mozgové nádory – diagnóza – liečba


Authors: V. Miskovska 1;  V. Usakova 2;  B. Vertakova-Krakovska 2;  B. Mrinakova 2;  V. Lehotská 3;  M. Chorvath 4;  B. Rychlý 5;  J. Steno 6;  D. Ondrus 1
Authors place of work: 1st Department of Oncology, Comenius University, Faculty of Medicine, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic 1;  Department of Medical Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic 2;  2nd Department of Radiodiagnostics, Comenius University, Faculty of Medicine, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic 3;  Department of Radiation Oncology, Slovak Medical University, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic 4;  Cytopathos, Bratislava, Slovak Republic 5;  Department of Neurosurgery, Comenius University, Faculty of Medicine, University Hospital, Bratislava, Slovak Republic 6
Published in the journal: Klin Onkol 2013; 26(1): 19-24
Category: Reviews

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Obdrženo: 25. 11. 2012

Přijato: 2. 12. 2012

Summary

Background:
Primary intracranial germ cell tumors represent a rare category of neoplasms, which occur in children and young adults. The WHO classification divides intracranial tumors into germinomas and non-germinomas. The most frequent locality of these tumors is pineal and suprasellar region. Clinical signs and symptoms depend on the localization of the tumour – they most commonly include signs of increased intracranial pressure, Parinaud’s syndrome, bitemporal hemianopsy and signs of endocrine deficiency. Gadolinium enhanced MRI scan of the brain is the imagining examination of choice in the diagnostic strategy of intracranial germ cell tumors. However, the imagining studies do not provide sufficient information about histological type; therefore, biopsy is necessary. The exception represents cases with characteristically increased levels of tumor markers (AFP and β-HCG) measured in the serum and cere­brospinal fluid.

Case:
A pineal germ cell tumor was observed in a 26-year-old male with pre­sentation of an eye-sight disorder with focusing difficulty and photophobia, accompanied by intensive fatigue and sleepiness, nausea with occasional vomiting, intermittent headaches and Parinaud’s syndrome. MRI examination of the brain showed tumor expansion in the pineal region and in the right part of the mesencephalon. Radical extirpation of the tumor in the pineal region was performed. The follow-up MRI scan of the brain revealed relapse of the disease. The patient underwent craniospinal radiation therapy with subsequent postoperative chemothe­rapy (regimen cisplatin and etoposide), three cycles in total. Currently, the patient is 30 months after finishing of oncological treatment in clinical remission of the disease.

Conclusion:
The treatment and prognosis of this neoplasm differ between particular categories. Germinomas have better survival rates than non-germinomas. A 5-year survival rate of germinoma patients after application of radiotherapy alone was > 90% of cases. The addition of chemotherapy lead to a decrease of the dose and minimalization of the irradiated area, with achievement of fewer side effects without a decrease of the curability. Non-germinomas are less radiosensitive than germinomas, but after the application of the adjuvant chemotherapy, survival benefit was achieved. However, the optimal management of these tumors remains controversial.

Key words:
pinealoma – germinoma – brain neoplasms – diagnosis – treatment

Introduction

Primary intracranial germ cell tumours represent a rare category of neoplasms, which predominantly occur in childhood and young adult age. The incidence of these tumours in children with brain malignancies is higher in the Far East (Japan 10.3%, Korea 11.2%, Taiwan 14%) than in western countries (Canada 3.3%, France 3.5%, USA 4.1%) [1–6]. The intracranial germ cell tumours share histologicalgenetic and treatment similarities with extracranial germ cell tumours [7,8].

The aim of this paper is to present our own experience with treatment of a patient with germ cell tumour of the pineal region.

Case report

26-year old man with 2–3 months history of diplopia, mydriasis and head­ache in frontal and occipital area was examined by regional neurologist, who stated the diagnosis of anincomplete lesion of the oculomotor nerve bilaterally, as a consequence of post-vaccination mesencephalitis after tetanus and diphtheria vaccination. Temporarily symptom improvement was achieved after the treatment. Three months later worsening of the clinical status occurred, moreover this time the eyesight dis­order with focusing difficulty and photophobiawas accompanied by intensive fatigue and sleepiness, nausea with occasional vomitus and intermittent head­ache. Parinaud’s syndrome was determined clinically. The patient was transported to the specialized higher--level medical facility, based on the CT scan findings of the tumour in the pineal region along with he three ventricular hydrocephalus, with the intention of surgical treatment.

An urgently performed MRI examination of the brain showed tumour expansion in the pineal region and in the right part of the mesencephalon, which had solid-cystic character with invasion into dorsal part of the thirdventricle and the compression of aqueduct of Sylvius, accompaniedby the obstructive hydrocephalus. The solid compound of the tumour was localized more closely to mid-line, 23 × 20 mm, the cystic compound of the tumour was localized right with caudal orientation, 17 × 12 mm. Poorly discoverable calcifications in the mid-line area on the margin of the tumour, 22 × 25 mm (Fig. 1a–c) were also presented on the MRI scans.

Fig. 1a. MRI T1-weighted postcontrast views – tumorous expansion of solid-cystic nature in the pineal region and in the right mesencephalon (arrows), penetrating the dorsal part of the 3rd ventricle with compressed aqueduct of Silvius and 3-ventricular hydrocephalus – sagital view. Fig. 1b. Coronal view. Fig. 1c. Transversal view.
Fig. 1a. MRI T1-weighted postcontrast views – tumorous expansion of solid-cystic nature in the pineal region and in the right mesencephalon (arrows), penetrating the dorsal part of the 3rd ventricle with compressed aqueduct of Silvius and 3-ventricular hydrocephalus – sagital view.
Fig. 1b. Coronal view.
Fig. 1c. Transversal view.

The ventriculoperitoneal (V-P) drainage of the obstructive hydrocephalus was performed on the second day after MRI examination. Two days later, the radical extirpation of the tumour in pineal region was performed via infratentorial approach with histological findings of germinoma (tumour with solid, alveolar growth, with cells characterized by a more apparent and voluminous cytoplasm and vesicular nuclei, lymphoid stroma is also evident (HE 200×), immunohistochemistry is positive for PLAP (200×) (Fig. 2, 3).

Fig. 2. Solid proliferation of neoplastic cells with voluminous clear cytoplasm and vesicular nuclei in the reactive lymphoid stroma, HE 400×.
Fig. 2. Solid proliferation of neoplastic cells with voluminous clear cytoplasm and vesicular nuclei in the reactive lymphoid stroma, HE 400×.

Fig. 3. Immunohistochemically depicted positivity of the neoplastic cells for PLAP (Placental Alkaline Phosphatase), 400×.
Fig. 3. Immunohistochemically depicted positivity of the neoplastic cells for PLAP (Placental Alkaline Phosphatase), 400×.

The follow-up MRI scan of the brain, performed three months later, revealed a relapse of the disease in margins of the resection’s cavity after extirpation of the germinoma in pineal region, with continuation into the thalamus on the right side and to upper mesencephalon with incipient infiltration of leptomeninges on the dorsal part of the nodus, the vertebral canal remained without signs of metastatic infiltration (Fig. 4 a–c).

Fig. 4a. MRI T1-weighted postcontrast views – recurrent disease in the edge of surgical resection cavity in pineal region with involvement of the right thalamus and of the upper mesencephalon (arrows) – sagital view. Fig. 4b. Coronal view. Fig. 4c. Transversal view.
Fig. 4a. MRI T1-weighted postcontrast views – recurrent disease in the edge of surgical resection cavity in pineal region with involvement of the right thalamus and of the upper mesencephalon (arrows) – sagital view.
Fig. 4b. Coronal view.
Fig. 4c. Transversal view.

The patient underwent craniospinal radiation therapy in total dose (TD) for brain 55.0 Gy and for spine 27.0 Gy with subsequent postoperative chemotherapy (scheme cisplatin and etoposide), overall three cycles.

Currently the patient is 30 months after accomplishment of oncological treatment in clinical remission of the disease, according to repeated follow-up MRI scans (Fig. 5 a–c). From aneurological point of view, the patient has no signs of Parinaud’s syndrome.

Fig. 5a. MRI T1-weighted postcontrast views – in the pineal region no detectable tumor, just a slight dilatation of the 3rd ventricle – sagital view. Fig. 5b. Coronal view. Fig. 5c. Transversal view.
Fig. 5a. MRI T1-weighted postcontrast views – in the pineal region no detectable tumor, just a slight dilatation of the 3rd ventricle – sagital view.
Fig. 5b. Coronal view.
Fig. 5c. Transversal view.

Discussion

The WHO classification divides intracranial tumours into germinomas and non-germinomas, which include choriocarcinoma, yolk sac tumour, embryonal carcinoma, teratoma (mature, immature and teratoma with malignant differentiation) and mixed germcell tumours [9]. Germinomas represent 50–70%, while non-germinomas the remaining third [10].

The most frequent locality of these tumours is pineal and neurohypophyseal (suprasellar) region, less commonly they occur in basal ganglia or other brain localities (e.g. thalamus) [11,12].

The age distribution of afflicted patients is unimodal, centering with an abrupt surge in frequency in the early pubertal years; 68% of patients are dia­gnosed between 10 and 21 years of age [10]. In our case report the age of the patient was 26 at the time of the diagnosis, which means he was an adult.

Clinical signs and symptoms depend on the tumour’s localization. Tumours in the pineal region usually compress and obstruct cerebral aqueduct, which leads to an increase of the intracranial pressure and consequently hydrocephalus. It is manifested by headache, nausea, vomitus and somnolence. Another possible presentation of the tumour in the pineal region is Parinaud’s syndrome (paralysis of upgaze, paralysis of downward gaze is less frequent, similarly to convergence disorder and/or convergence-retraction nystagmus). Parinaud’s syndrome, partial or complete, is present in half of the patients [13]. As a result of the compression of optic chiasm, tumours localized in suprasellar region usually present with bitemporal hemianopsia and decrease of the visus. Invasion of the tumour into adenohypophysis causes endocrine deficiency, such as the delay of puberty in children and sexual dysfunction in adults, as an outcome of gonadoliberin deprival. Moreover the growth retardation can occur in children. Many of the suprasellar tumours manifest by the dysfunction of neurohypophysis leading to diabetes insipidus [12,14,15].

Germ cell tumours produce specific markers that are measurable in the serum and cerebrospinal fluid [16]. Increased values of AFP occur in yolk sac tumours, lower values are observed in mixed germ cell tumours and immature teratoma with syncytiotrophoblastic activity. However the pure germinoma can secrete relatively low levels of the β-hCG, highest values are typically associated with choriocarcinoma [17]. The assessment of alkaline phosphatase is used more in immunohistochemistry, its positivity is diagnostically significant for germinomas [18,19]. Gadolinium enhanced MRI scan of the brain is the imagining examination of choice in the diagnostic strategy of intracranial germ cell tumours. In case of inaccessibility to a MRI, CT examination is also convenient [20,21]. The calcifications of the tumours in pineal region occur in as much as 70% of cases, however this finding is not common in pediatric patients, hence the X-ray of the skull may lead to diagnosis of the pineal tumour [22]. For the diagnosis of the potential leptomeningeal infiltration it is vital to perform a MRI of the spinal cord [23,24].

The obstructive hydrocephalus is a clinical sign of many patients with tumours in the pinealregion, which usually requires the implantation of a ventriculoperitoneal shunt or endoscopic ventriculostomy of the third ventricule [25]. The imagining studies do not provide sufficient information about histological type, therefore the biopsy is necessary [26]. The exception represents cases with characteristically increased levels of tumour markers [27]. The importance of partial or complete resection of the germinoma was not defined and the role of a radical resection in non-germinoma is still unclear, although the complete resection of patients with mature teratoma has a curative effect [28–30]. In patients with non-germinoma, who didn’t reach complete radiographic response afterchemotherapy and who’s tumour marker levels have been normalized, the  “second-look surgery” should be considered. The histological finding may include necrosis or fibrosis, but the so-called growing teratoma syndrome may also be detected, in this case surgical treatment is the sole curative modality [31]. Likewise the “Second-look surgery” is advised for a better histological evaluation and confirmation of the presence of residual malignant elements, in a situation, when the normalized tumour marker levels are not reached.

Germinomas are radiosensitive tumours. 5-year survival after application of radiotherapy alone is more than 90% of cases. According to these excellent results and also the side effects in children, such as influence on growth, cognitive functions and neuroendocrine develop­ment [32–34], various authors concentrated on lowering the doses with the intention of reducing side effects [35,36]. Several studies draw the conclusion that craniospinal radiotherapy is not essential in localized germinomas [37]. Combined chemotherapy regimens based on platinum showed high treatment efficacy in testicular germ cell tumours, consequently germ cell tumours in the CNS had also become candidates for chemotherapy. Fouladi et al [38] and Sawamara et al [39] achieved comparable results of survival with the use of platinum based chemotherapy and low doses of radiotherapy. Aomaya et al [40] applied three or four cycles of platinum based chemotherapy, depending on the resec­tion extend, with sequential application of radio­therapy in the dose of 27.0 Gy towards affected area. The overall 5-year survival and disease free survival for pure germinoma was 100%, resp. 86%. In patients with germinoma with increased values of β-hCG the overall survival, resp. disease free survival was 100%, resp. 44%.

The non-germinomas are less radiosensitive than pure germinomas. The prognosis in patients treated with craniospinal radiotherapy alone is worse, with 5-year survival 30–50% and early relapse of the disease [14,41]. The addition of chemotherapy may improve the overall survival of patients with non-germinomas of the CNS [42–45]. Radiotherapy remains a vital accepted treatment strategy in the therapy of non-germinomas of the CNS. However, the necessity of craniospinal radiotherapy versus “focal or whole-ventricular radiotherapy” remains controversial, particularly in patients with localized disease [27].

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Miskovska Vera, MD, Ph.D.

1st Department of Oncology, Comenius University, Faculty of Medicine

St. Elisabeth Cancer Institute

Heydukova 10

812 50 Bratislava

Slovak Republic

e-mail: vieramiskovska@yahoo.fr

Submitted: 25. 11. 2012

Accepted: 2. 12. 2012


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Štítky
Paediatric clinical oncology Surgery Clinical oncology

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Clinical Oncology

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