History and the present state of hypolipidaemic therapy

Česká verzia

Authors: R. Bartas ¹; J. Kolář ²
Authors place of work: Lékárna Aqua, Karviná ¹; Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav aplikované farmacie ²
Published in the journal: Čes. slov. Farm., 2008; 57, 208-214
Category: Přehledy a odborná sdělení

Summary

History of hypolipidaemic therapy is closely connected with the development of the knowledge of atherosclerosis pathogenesis and lipid metabolism. Isolation of statins (and also their synthesis) and their subsequent implementation in practice were a decisive discovery that affected contemporary cardiology. Statins rank among the most widely utilized drugs and some of them belong to very commercially successful preparations. There are very few therapeutic groups the therapeutic contribution of which is documented so well. Several prospective drugs with different mechanisms of effect are being developed at present.

Keywords:
hypolipidaemics – atherosclerosis – ischemic heart disease – statins

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