Clinical significance of cytochrome P450 genetic polymorphism – Part I. Enzymatic system of cytochrome P450 and cytochrome P450 1A2

Česká verzia

Authors: Jana Ďuricová; Milan Grundmann
Authors place of work: Ostravská Univerzita v Ostravě, Lékařská fakulta, Ústav klinické farmakologie FN
Published in the journal: Čes. slov. Farm., 2011; 60, 110-115
Category: Přehledy a odborná sdělení

Summary

Inter-individual variability in drug response is a major clinical problem. Much of the variability has been observed in drug metabolism, particularly in the enzymes of cytochrome P450. Genetic polymorphism in these enzymes may influence a patient’s response to commonly prescribed drugs. The first part of this review describes the enzymatic system of cytochrome P450 and further focuses on the influence of genetic polymorphism of cytochrome P450 1A2 on drug effect.

Key words:
cytochrome P450 – genetic polymorphism – CYP1A2

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