Cellular and molecular mechanisms of action of bitter compounds: recent knowledge and perspective

Česká verzia

Authors: Milan Nagy; Pavel Mučaji
Authors place of work: Katedra farmakognózie a botaniky, Farmaceutická fakulta Univerzity Komenského v Bratislave
Published in the journal: Čes. slov. Farm., 2016; 65, 132-138
Category: Přehledy a odborná sdělení

*Venované Dr.h.c. prof. RNDr. Václavovi Suchému, DrSc. pri príležitosti jeho životného jubilea.

Summary

This overview paper describes in its introductory part bitter-tasting herbal drugs in the context of their traditional use in the loss of appetite and digestive disorders. Then, it mentions current knowledge on signals origin in bitter taste receptors leading to different, unexpected physiological processes. Newly observed biological effects of bitter tastants are correlated with modern trends of their complex study with an aim to develop new drugs primarily acting on bitter taste receptors.

Key words:
T2R • bitter taste receptors • GPCR • bitters • glucose homeostasis • asthma • ghrelin • GLP-1 • solitary chemosensory cells

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