The Libechov Minipig as a Large Animal Model for Preclinical Research in Huntington’s disease – Thoughts and Perspectives
The Libechov Minipig as a Large Animal Model for Preclinical Research in Huntington’s disease – Thoughts and Perspectives
Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.
Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.
Autoři:
S. Schramke 1,2; R. Schubert 1; F. Frank 1,3; M. Wirsig 1; M. Fels 2; N. Kemper 2; V. Schuldenzucker 1; R. Reilmann 1,3,4
Působiště autorů:
George-Huntington-Institute, Muenster, Germany
1; Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour, University of Veterinary Medicine Hannover, Germany
2; Institute for Clinical Radiology, University of Muenster, Germany
3; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Germany
4
Vyšlo v časopise:
Cesk Slov Neurol N 2015; 78/111(Supplementum 2): 55-60
prolekare.web.journal.doi_sk:
https://doi.org/10.14735/amcsnn20152S55
Souhrn
Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.
Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.
Zdroje
1. Chang KH, Wu YR, Chen YC, Chen CM. Plasma inflammatory biomarkers for Huntington‘s disease patients and mouse model. Brain Behav Immun 2015; 44: 121– 127. doi: 10.1016/ j.bbi.2014.09.011.
2. Ross CA, Pantelyat A, Kogan J, Brandt J. Determinants of functional disability in Huntington‘s disease: role of cognitive and motor dysfunction. Mov Disord 2014; 29: 1351– 1358. doi: 10.1002/ mds.26012.
3. Walker FO. Huntington‘s disease. Lancet 2007; 369(9557): 218– 228.
4. Aylward EH, Harrington DL, Mills JA, Nopoulos PC, Ross CA, Long JD et al. Regional atrophy associated with cognitive and motor function in prodromal Huntington‘s disease. J Huntingtons Dis 2013; 2(4): 477– 489. doi: 10.3233/ JHD‑ 130076.
5. MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington‘s disease chromosomes. Cell 1993; 72(6): 971– 983.
6. Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D et al. Biological and clinical manifestations of Huntington‘s disease in the longitudinal TRACK‑ HD study: cross‑ sectional analysis of baseline data. Lancet Neurol 2009; 8(9): 791– 801. doi: 10.1016/ S1474‑ 4422(09)70170‑ X.
7. Tabrizi SJ, Scahill RI, Owen G, Durr A, Leavitt BR, Roos RAet al. Predictors of phenotypic progression and disease onset in premanifest and early‑stage Huntington‘s disease in the TRACK‑ HD study: analysis of 36- month observational data. Lancet Neurol 2013; 12(7): 637– 649. doi: 10.1016/ S1474‑ 4422(13)70088‑ 7.
8. The Huntington‘s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington‘s disease chromosomes. Cell 1993; 72(6): 971– 983.
9. Morton AJ, Howland DS. Large genetic animal models of Huntington‘s disease. J Huntingtons Dis 2013; 2(1): 3– 19. doi: 10.3233/ JHD‑ 130050.
10. Pouladi MA, Morton AJ, Hayden MR. Choosing an animal model for the study of Huntington‘s disease. Nat Rev Neurosci 2013; 14(10): 708– 721. doi: 10.1038/ nrn3570.
11. Crook ZR, Housman D. Huntington‘s disease: can mice lead the way to treatment? Neuron 2011; 69(3): 423– 435. doi: 10.1016/ j.neuron.2010.12.035.
12. Kim J, Bordiuk OL, Ferrante RJ. Experimental models of HD and reflection on therapeutic strategies. Int Rev Neurobiol 2011; 98: 419– 481. doi: 10.1016/ B978‑ 0‑ 12‑ 381328‑ 2.00016‑ X.
13. William YX, Gray M. Mouse Models for Validating Preclinical Candidates for Huntington‘s Disease. In Lo DC, Hughes RE (eds). Neurobiology of Huntington‘s disease: Applications to Drug Discovery. CRC Press: Boca Raton 2011.
14. Venuto CS, McGarry A, Ma Q, Kieburtz K. Pharmacologic approaches to the treatment of Huntington‘s disease. Mov Disord 2012; 27(1): 31– 41. doi: 10.1002/ mds.23953.
15. Baxa M, Hruska‑ Plochan M, Juhas S, Vodicka P, Pavlok A,Juhasova J et al. A transgenic minipig model of Huntington‘s disease. J Huntingtons Dis 2013; 2(1): 47– 68. doi: 10.3233/ JHD‑ 130001.
16. Ott S, Schramke S, Schuldenzucker V, Wirsig M, Schubert R, Frank F et al. Track tgHD Minipig – Assessing Resource Holding Potential Behaviour as part of a Battery for Phenotyping tgHD Minipigs. J Neurol Neurosurg Psychiatry 2014; 85: A31.
17. Schramke S, Schuldenzucker V, Schubert R, Frank F, Wirsig M, Ott S et al. Behavioral phenotyping of minipigs transgenic for the Huntington gene. Unpublished.
18. Schramke S, Schuldenzucker V, Ott S, Wirsig M, Frank F,Schubert R et al. Track TgHD minipigs – Discrimination Test as a part of an assessment battery for TgHD minipigs. J Neurol Neurosurg Psychiatry 2014; 85: A31.
19. Schuldenzucker V, Schramke S, Wirsig M, Ott S, Schubert R, Frank F et al. Track TgHD minipig – assessment of motor function. J Neurol Neurosurg Psychiatry 2014; 85: A30.
20. Wirsig M, Schuldenzucker V, Schramke S, Frank F, Schubert R, Ott S et al. Track TgHD minipig – Startbox back and Forth Test. J Neurol Neurosurg Psychiatry 2014; 85: A30– A31.
21. Frank F, Nagelmann N, Liebsch L, Schubert R, Wirsig M, Schramke S al. Striatal Magnetic Resonance Spectroscopy of Transgenic HD Minipigs. J Neurol Neurosurg Psychiatry 2014; 85: A29– A30.
22. Nagelmann N, Frank F, Liebsch L, Schubert R, Wirsig M,Schramke S et al. Volumetry of Nucleus Caudatus, Lateral Ventricles and Cerebrum of Founder and Second Generation Libechov Transgenic HD Minipigs. J Neurol Neurosurg Psychiatry 2014; 85: A29.
23. Schubert R, Frank F, Nagelmann N, Liebsch L, Schuldenzucker V, Schramke S et al. Neuroimaging of a minipig model of Huntington‘s disease: feasibility of volumetric, diffusion‑ weighted and spectroscopic assessments. Unpublished.
24. Schubert R, Frank F, Nagelmann N, Schramke S, Schuldenzucker V et al. MR‑based Stereotaxic Standard Brain Atlas Of The Libechov Minipig. J Neurol Neurosurg Psychiatry 2014; 85: A29.
25. Nickel R, Schummer A, Frewein J, Seiferle E. Eingeweide. Lehrbuch der Anatomie der Haustiere 2. Stuttgart: Parey 2004.
26. Wolfensohn S, Lloyd M. Handbook of Laboratory Animal Management and Welfare. Wiley: Blackwell Publishing 2013.
27. Boujard D, Anselme B, Cullin C, Raguénès‑ Nicol C, Lechowski S. Zell‑ und Molekularbiologie im Überblick. Berlin: Springer Heidelberg 2014.
28. Busch B, Blaha T. Der Tierheim‑ Leitfaden: management und artgemäße Haltung. Verlag: Schattauer 2013.
29. Gabrisch K, Fehr PD, Sassenburg L, Zwart PD. Krankheiten der Heimtiere. Sassenbrug: Schlütersche Verlagsgesellschaft mbH & Company KG 2014.
30. Hagemann E, Schmidt GE. Ratte und Maus: versuchstiere in der Forschung. Berlin: W. de Gruyter 1960.
31. McAnulty PA, Dayan AD, Ganderup NC, Hastings KL. The Minipig in Biomedical Research. Boca Raton: CRC Press 2011.
32. Vodicka P, Smetana K jr, Dvorankova BF, Emerick TF, Xu YZ, Ourednik J et al. The miniature pig as an animal model in biomedical research. Ann N Y Acad Sci 2005; 1049: 161– 171.
33. Weiss J, Becker K, Bernsmann E, Chourbaji S, Dietrich H.Versuchstierkunde: Tierpflege in Forschung und Klinik. Berlin: Enke 2014.
34. Bollen PF, Ellegaard L. The Gottingen minipig in pharmacology and toxicology. Pharmacol Toxicol 1997; 80 (Suppl 2): 3– 4.
35. Bollen PJ, Hansen AK, Alstrup AK. The Laboratory Swine. 2nd ed. Washington: CRC Press 2010.
36. Böhme G. Lehrbuch der Anatomie der Haustiere Band 4: Nervensystem, Sinnesorgane, Endokrine Drüsen. Berlin: Parey 2004.
37. Jelsing J, Gundersen H jr, Nielsen R, Hemmingsen R, Pakkenberg B. The postnatal development of cerebellar Purkinje cells in the Goettingen minipig estimated with a new stereological sampling technique – the vertical bar fractionator. J Anatomy 2006; 209: 321– 331.
38. Jerison H. Evolution of The Brain and Intelligence. New York: Elsevier Science 2012.
39. Roth G. Das Gehirn und seine Wirklichkeit: kognitive Neurobiologie und ihre philosophischen Konsequenzen. Berlin: Suhrkamp 1997.
40. Flecknell P. Replacement, reduction and refinement. Altex 2002; 19(2): 73– 78.
41. Bjarkam CR, Cancian G, Glud AN, Ettrup KS, Jorgensen RL, Sorensen JC. MRI‑ guided stereotaxic targeting in pigs based on a stereotaxic localizer box fitted with an isocentric frame and use of SurgiPlan computer‑ planning software. J Neurosci Methods 2009; 183(2): 119– 126. doi: 10.1016/ j.jneumeth.2009.06.019.
42. Kosinski C, Cha JH, Young AB, Schwarz M. Chorea Huntington Tiermodelle eröffnen neue Hypothesen zu Pathophysiologie und Therapie. Nervenarzt 1999; 70(10): 878– 888.
Štítky
Detská neurológia Neurochirurgia NeurológiaČlánok vyšiel v časopise
Česká a slovenská neurologie a neurochirurgie
2015 Číslo Supplementum 2
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Fixní kombinace paracetamol/kodein nabízí synergické analgetické účinky
- Kombinace metamizol/paracetamol v léčbě pooperační bolesti u zákroků v rámci jednodenní chirurgie
- Tramadol a paracetamol v tlumení poextrakční bolesti
- Antidepresivní efekt kombinovaného analgetika tramadolu s paracetamolem
Najčítanejšie v tomto čísle
- The Libechov Minipig as a Large Animal Model for Preclinical Research in Huntington’s disease – Thoughts and Perspectives
- Epiteliální buňky bukálního stěru jako potenciální neinvazivní biologický materiál pro monitorování mitochondriálních dysfunkcí v průběhu rozvoje Huntingtonovy choroby – pilotní studie
- Abstracts
- Monitoring fyzické aktivity u miniprasečího modelu Huntingtonovy nemoci