Současné dvě EGFR mutace u plicního adenokarcinomu – kazuistika

Cílená terapie pomocí EGFR‑ TKIs (epidermal growth factor receptor‑ tyrosine kinase inhibitors) je v současné době dobře zavedenou léčbou pro pacienty s tzv. častými EGFR mutacemi s pokročilým nebo metastatickým nemalobuněčným karcinomem plic. Účinnost této léčby pro tzv. vzácné a obzvláště pak pro tzv. komplexní EGFR mutace není zcela jasná. V naší kazuistice popisujeme případ 63leté ženy s metastatickým nemalobuněčným karcinomem plic s komplexní EGFR mutací (G719X + S768I), která byla léčena gefitinibem. Doba do progrese dosáhla osm měsíců. Následně diskutujeme naší kazuistiku s literárně zveřejněmými obdobnými případy. Celkově se zdá, že popisovaná komplexní mutace má relativně dobrou citlivost pro léčbu pomocí EGFR‑ TKIs.

Klíčová slova:
nemalobuněčný karcinom plic – EGFR gen – EGFR protein – complex mutations – rare EGFR mutations – EGFR‑ TKIs

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Obdrženo:
24. 11. 2014

Přijato:
4. 2. 2015

Autoři: M. Svaton ¹; M. Pesek ¹; Z. Chudacek ²; H. Vosmiková ³
Působiště autorů: Department of Pneumology, Charles University in Prague, Faculty of Medicine in Pilsen, University Hospital Pilsen, Czech Republic ¹; Department of Radiology, Charles University in Prague, Faculty of Medicine in Pilsen, University Hospital Pilsen, Czech Republic ²; Department of Pathology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Czech Republic ³
Vyšlo v časopise: Klin Onkol 2015; 28(2): 134-137
Kategorie: Kazuistika
prolekare.web.journal.doi_sk: https://doi.org/10.14735/amko2015134

Souhrn

Obdrženo:
24. 11. 2014

Přijato:
4. 2. 2015

Zdroje

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