Alternative Mechanisms for Tn Transposition

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Bacterial transposons are known to move to new genomic sites using either a replicative or a conservative mechanism. The behavior of transposon Tn5 is anomalous. In vitro studies indicate that it uses a conservative mechanism while in vivo results point to a replicative mechanism. To explain this anomaly, a model is presented in which the two mechanisms are not independent—as widely believed—but could represent alternate outcomes of a common transpositional pathway.

Vyšlo v časopise: Alternative Mechanisms for Tn Transposition. PLoS Genet 5(8): e32767. doi:10.1371/journal.pgen.1000619
Kategorie: Review
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1000619

Souhrn

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