Fish mutant, where is thy phenotype?

1. Sjoberg EA. Logical fallacies in animal model research. Behav Brain Funct. 2017;13(1):3. doi: 10.1186/s12993-017-0121-8 28202023; PubMed Central PMCID: PMCPMC5312558.

2. Jao LE, Wente SR, Chen WB. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(34):13904–9. doi: 10.1073/pnas.1308335110 PubMed PMID: WOS:000323271400055. 23918387

3. Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nature biotechnology. 2013;31(3):227–9. doi: 10.1038/nbt.2501 23360964; PubMed Central PMCID: PMC3686313.

4. Gagnon JA, Valen E, Thyme SB, Huang P, Ahkmetova L, Pauli A, et al. Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. PLoS ONE. 2014;9(5):e98186. doi: 10.1371/journal.pone.0098186 24873830; PubMed Central PMCID: PMC4038517.

5. Nasevicius A, Ekker SC. Effective targeted gene 'knockdown' in zebrafish. Nature genetics. 2000;26(2):216–20. doi: 10.1038/79951 11017081.

6. Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, et al. Guidelines for morpholino use in zebrafish. PLoS Genet. 2017;13(10):e1007000. doi: 10.1371/journal.pgen.1007000 29049395; PubMed Central PMCID: PMCPMC5648102.

7. Rossi A, Kontarakis Z, Gerri C, Nolte H, Holper S, Kruger M, et al. Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 2015;524(7564):230–3. doi: 10.1038/nature14580 26168398.

8. Anderson JL, Mulligan TS, Shen MC, Wang H, Scahill CM, Tan FJ, et al. mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. PLoS Genet. 2017;13(11):e1007105. doi: 10.1371/journal.pgen.1007105 29161261; PubMed Central PMCID: PMCPMC5716581.

9. Jagannathan S, Bradley RK. Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population. Genome Res. 2016;26(12):1639–50. doi: 10.1101/gr.205070.116 27646533; PubMed Central PMCID: PMCPMC5131816.

10. Baradaran-Heravi A, Niesser J, Balgi AD, Choi K, Zimmerman C, South AP, et al. Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(13):3479–84. doi: 10.1073/pnas.1620982114 28289221; PubMed Central PMCID: PMCPMC5380045.

11. Kok FO, Shin M, Ni CW, Gupta A, Grosse AS, van Impel A, et al. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Dev Cell. 2015;32(1):97–108. doi: 10.1016/j.devcel.2014.11.018 25533206; PubMed Central PMCID: PMCPMC4487878.

12. El-Brolosy MA, Stainier DYR. Genetic compensation: A phenomenon in search of mechanisms. PLoS Genet. 2017;13(7):e1006780. doi: 10.1371/journal.pgen.1006780 28704371; PubMed Central PMCID: PMCPMC5509088.

13. Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002;418(6896):387–91. doi: 10.1038/nature00935 12140549.