Murid Herpesvirus-4 Exploits Dendritic Cells to Infect B Cells

1. SteinmanRM 1991 The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9 271 296

2. JoffreONolteMASpörriRReiseSousaC 2009 Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol Rev 227 234 247

3. MacatoniaSETaylorPMKnightSCAskonasBA 1989 Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J Exp Med 169 1255 1264

4. BhardwajNBenderAGonzalezNBuiLKGarrettMC 1994 Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J Clin Invest 94 797 807

5. ZinkernagelRM 2002 On cross-priming of MHC class I-specific CTL: rule or exception? Eur J Immunol 32 2385 2392

6. FreigangSProbstHCvan den BroekM 2005 DC infection promotes antiviral CTL priming: the ‘Winkelried’ strategy. Trends Immunol 26 13 18

7. KnightSCMacatoniaSECruickshankKRudgePPattersonS 1993 Dendritic cells in HIV-1 and HTLV-1 infection. Adv Exp Med Biol 329 545 549

8. SalioMCellaMSuterMLanzavecchiaA 1999 Inhibition of dendritic cell maturation by herpes simplex virus. Eur J Immunol 29 3245 3253

9. RappoccioloGJenkinsFJHenslerHRPiazzaPJaisM 2006 DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. J Immunol 176 1741 1749

10. SinclairJ 2008 Manipulation of dendritic cell functions by human cytomegalovirus. Expert Rev Mol Med 10 e35

11. AndrewsDMAndoniouCEGranucciFRicciardi-CastagnoliPDegli-EspostiMA 2001 Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat Immunol 2 1077 1084

12. RafteryMJSchwabMEibertSMSamstagYWalczakH 2001 Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy. Immunity 15 997 1009

13. StevensonPGSimasJPEfstathiouS 2009 Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4. J Gen Virol 90 2317 2330

14. SpeckSHGanemD 2010 Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host Microbe 8 100 115

15. Sunil-ChandraNPEfstathiouSNashAA 1992 Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo. J Gen Virol 73 3275 3279

16. FlañoEKimIJWoodlandDLBlackmanMA 2002 Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J Exp Med 196 1363 1372

17. WeckKEBarkonMLYooLISpeckSHVirginHW 1996 Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68. J Virol 70 6775 6780

18. FlañoEHusainSMSampleJTWoodlandDLBlackmanMA 2000 Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. J Immunol 165 1074 1081

19. MarquesSEfstathiouSSmithKGHauryMSimasJP 2003 Selective Gene Expression of Latent Murine Gammaherpesvirus 68 in B Lymphocytes. J Virol 77 7308 7318

20. GangappaSKapadiaSBSpeckSHVirginHW 2002 Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice. J Virol 76 11460 11468

21. Guerreiro-CacaisAOLiLDonatiDBejaranoMTMorganA 2004 Capacity of Epstein-Barr virus to infect monocytes and inhibit their development into dendritic cells is affected by the cell type supporting virus replication. J Gen Virol 85 2767 2778

22. HoaglandRJ 1964 The incubation period of infectious mononucleosis. Am J Public Health Nations Health 54 1699 1705

23. FaulknerGCKrajewskiASCrawfordDH 2000 The ins and outs of EBV infection.e Trends Microbiol 8 185 189

24. SokalEMHoppenbrouwersKVandermeulenCMoutschenMLéonardP 2007 Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults. J Infect Dis 196 1749 1753

25. MoserJMFarrellMLKrugLTUptonJWSpeckSH 2006 A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge. J Virol 80 1592 1598

26. KayhanBYagerEJLanzerKCookenhamTJiaQ 2007 A replication-deficient murine gamma-herpesvirus blocked in late viral gene expression can establish latency and elicit protective cellular immunity. J Immunol 179 8392 8402

27. TibbettsSALohJvan BerkelVMcClellanJSJacobyMA 2003 Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection. J Virol 77 7696 7701

28. JarousseNChandranBCoscoyL 2008 Lack of heparan sulfate expression in B-cell lines: implications for Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 infections. J Virol 82 12591 12597

29. MilhoRSmithCMMarquesSAlenquerMMayJS 2009 In vivo imaging of murid herpesvirus-4 infection. J Gen Virol 90 21 32

30. GillMBWrightDESmithCMMayJSStevensonPG 2009 Murid herpesvirus-4 lacking thymidine kinase reveals route-dependent requirements for host colonization. J Gen Virol 90 1461 1470

31. GillMBMayJSColacoSStevensonPG 2010 Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract. J Virol 84 10937 10942

32. PopeMBetjesMGRomaniNHirmandHCameronPU 1994 Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78 389 398

33. LekkerkerkerANvan KooykYGeijtenbeekTB 2006 Viral piracy: HIV-1 targets dendritic cells for transmission. Curr HIV Res 4 169 176

34. MacPhersonGKushnirNWykesM 1999 Dendritic cells, B cells and the regulation of antibody synthesis. Immunol Rev 172 325 334

35. PiguetVSteinmanRM 2007 The interaction of HIV with dendritic cells: outcomes and pathways. Trends Immunol 28 503 510

36. JungSUnutmazDWongPSanoGde los SantosK 2002 In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17 211 220

37. OghisoYMatsuokaO 1979 Distribution of colloidal carbon in lymph nodes of mice injected by different routes. Jpn J Exp Med 49 223 234

38. UsherwoodEJStewartJPRobertsonKAllenDJNashAA 1996 Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice. J Gen Virol 77 2819 2825

39. MayJSStevensonPG 2010 Vaccination with murid herpesvirus-4 glycoprotein B reduces viral lytic replication but does not induce detectable virion neutralization. J Gen Virol 91 2542 2552

40. StevensonPGDohertyPC 1999 Non-antigen-specific B-cell activation following murine gammaherpesvirus infection is CD4 independent in vitro but CD4 dependent in vivo. J Virol 73 1075 1079

41. YamashitaYOritaniKMiyoshiEKWallRBernfieldM 1999 Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes. J Immunol 162 5940 5948

42. GilletLMayJSStevensonPG 2009 In vivo importance of heparan sulfate-binding glycoproteins for murid herpesvirus-4 infection. J Gen Virol 90 602 613

43. SacherTPodlechJMohrCAJordanSRuzsicsZ 2008 The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host. Cell Host Microbe 3 263 272

44. AdlerHMesserleMWagnerMKoszinowskiUH 2000 Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome. J Virol 74 6964 6974

45. SmithCMGillMBMayJSStevensonPG 2007 Murine gammaherpesvirus-68 inhibits antigen presentation by dendritic cells. PLoS One 2 e1048

46. SongMJHwangSWongWHWuTTLeeS 2005 Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis. Proc Natl Acad Sci USA 102 3805 3810

47. HusainSMUsherwoodEJDysonHColecloughCCoppolaMA 1999 Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8(+) T lymphocytes. Proc Natl Acad Sci USA 96 7508 7513

48. BowdenRJSimasJPDavisAJEfstathiouS 1997 Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency. J Gen Virol 78 1675 1687

49. ColemanHMEfstathiouSStevensonPG 2005 Transcription of the murine gammaherpesvirus 68 ORF73 from promoters in the viral terminal repeats. J Gen Virol 86 561 574

50. EfstathiouSHoYMMinsonAC 1990 Cloning and molecular characterization of the murine herpesvirus 68 genome. J Gen Virol 71 1355 1364

51. StevensonPGMayJSSmithXGMarquesSAdlerH 2002 K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus. Nat Immunol 3 733 740

52. de LimaBDMayJSMarquesSSimasJPStevensonPG 2005 Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo. J Gen Virol 86 31 40

53. FlañoEKayhanBWoodlandDLBlackmanMA 2005 Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation. J Immunol 175 3225 3234

54. HochreiterRPtaschinskiCKunkelSLRochfordR 2007 Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J Gen Virol 88 1896 1905

55. GretzJENorburyCCAndersonAOProudfootAEShawS 2000 Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med 192 1425 1440

56. PapeKACatronDMItanoAAJenkinsMK 2007 The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26 491 502

57. RoozendaalRMempelTRPitcherLAGonzalezSFVerschoorA 2009 Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30 264 276

58. PhanTGGrigorovaIOkadaTCysterJG 2007 Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol 8 992 1000

59. CarrascoYRBatistaFD 2007 B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 27 160 171

60. JuntTMosemanEAIannaconeMMassbergSLangPA 2007 Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450 110 114

61. GonzalezSFLukacs-KornekVKuligowskiMPPitcherLADegnSE 2010 Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nat Immunol 11 427 434

62. RandolphGROchandoJPartida-SánchezS 2008 Migration of Dendritic Cell Subsets and their Precursors. Ann. Rev. Immunol. 26 293 316

63. Sunil-ChandraNPEfstathiouSArnoJNashAA 1992 Virological and pathological features of mice infected with murine gamma-herpesvirus 68. J Gen Virol 73 2347 2356

64. MayJSWalkerJColacoSStevensonPG 2005 The murine gammaherpesvirus 68 ORF27 gene product contributes to intercellular viral spread. J Virol 79 5059 5068

65. GilletLMayJSColacoSStevensonPG 2007 Glycoprotein L disruption reveals two functional forms of the murine gammaherpesvirus 68 glycoprotein H. J Virol 81 280 291

66. de LimaBDMayJSStevensonPG 2004 Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo. J Virol 78 5103 5112

67. NashAADutiaBMStewartJPDavisonAJ 2001 Natural history of murine gamma-herpesvirus infection. Philos Trans R Soc Lond B Biol Sci 356 569 579

68. HumeDA 2011 Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. J Leukoc Biol 89 525 538

69. ClausenBEBurkhardtCReithWRenkawitzRForsterI 1999 Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8 265 277

70. UsherwoodEJRossAJAllenDJNashAA 1996 Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cells. J Gen Virol 77 627 630

71. Le ClaincheCCarlierMF 2008 Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 88 489 513

72. GillMBEdgarRMayJSStevensonPG 2008 A gamma-herpesvirus glycoprotein complex manipulates actin to promote viral spread. PLoS One 3 e1808

73. RiceJde LimaBStevensonFKStevensonPG 2002 A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope. Eur J Immunol 32 3481 3487

74. StevensonPG 2004 Immune evasion by gamma-herpesviruses. Curr Opin Immunol 16 456 462

75. MountAMMassonFKupresaninFSmithCMMayJS 2010 Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection. J Immunol 185 3669 3676

76. CatonMLSmith-RaskaMRReizisB 2007 Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med 204 1653 1664

77. MayJSSmithCMGillMBStevensonPG 2008 An essential role for the proximal but not the distal cytoplasmic tail of glycoprotein M in murid herpesvirus 4 infection. PLoS One 3 e2131

78. HoessRHWierzbickiAAbremskiK 1986 The role of the loxP spacer region in P1 site-specific recombination. Nucleic Acids Res 14 2287 2300

79. MayJSColemanHMBonameJMStevensonPG 2005 Murine gammaherpesvirus-68 ORF28 encodes a non-essential virion glycoprotein. J Gen Virol 86 919 928

80. VirginHWLatreillePWamsleyPHallsworthKWeckKE 1997 Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71 5894 5904

81. GasparMGillMBLösingJBMayJSStevensonPG 2008 Multiple functions for ORF75c in murid herpesvirus-4 infection. PLoS One 3 e2781