Fractioned plasmatic separation and adsorption has no influence on the haemodynamic parameters in experimental acute liver failure
Authors:
Lásziková Eva 1,5; Pražák Josef 2; Pantoflíček Tomáš 3,5; Ryska Ondřej 3; Koblihová Eva 3,5; Jurenka Božetěch 1; Ryska Miroslav 3,5
Authors place of work:
Anesteziologicko-resuscitační oddělení ÚVN Praha
1; Klinika anesteziologie, resuscitace a intenzivní péče 2. LF UK a ÚVN Praha
2; Chirurgická klinika 2. LF UK a ÚVN Praha
3; Chirurgická klinika 1. LF Praha UK, Nemocnice na Bulovce, Praha
4; Centrum buněčné terapie a tkáňových náhrad 2. LF UK a ÚVN Praha
5
Published in the journal:
Anest. intenziv. Med., 21, 2010, č. 4, s. 191-198
Category:
Intensive Care Medicine - Original Paper
Summary
Objective:
Acute liver failure (ALF) is a relatively sparse disease with a very poor prognosis. Its onset is accompanied by haemodynamic instability. The aim of our study was to evaluate the influence of fractioned plasmatic separation and adsorption (FPSA) on the haemodynamics using an ALF experimental model in large laboratory animals, comparing the results of the experimental and control groups.
Design:
Experimental study.
Setting:
Department of Anaesthesiology and Resuscitation, Central Military Hospital, Prague.
Materials and methods:
Our experiment included 21 laboratory pigs ( 25–45 kg ) with ALF induced by surgical devascularization. The onset of ALF was documented by hypoglycaemia (< 3.5 mmol/l). FPSA therapy was commenced in 14 of the animals, the remaining animals were used as the control group. We reported the haemodynamic parameters at hour 0, 3, 6, 9 and 12 of our experiment, as well as the biochemical parameters and intracranial pressure (ICP). The results were statistically analysed using the T-test and Mann-Whitney’s test. A difference greater than pResults: As compared with the values measured at the beginning of our experiment, a significant decrease of systemic vascular resistance index (SVRI) determined at hour 3, 6, 9, and 12 of our experiment, and a significant increase of the heart rate (HR) and cardiac index (CI) at hour 6, 9, and 12 of the experiment were noted in both the groups. Compared to the control group, we did not find any significant difference of mean arterial pressure (MAP), systemic vascular resistance index (SVRI) and lactate (p > 0.05) in the experimental group of animals treated with FPSA therapy. A significant decrease of ICP (p < 0.05), a significant decrease of HR at hour 3, a significant increase of CI at hour 9 and a significant decrease of pulmonary artery wedge pressure (PAWP) at hours 6 and 12 were observed.
Conclusion:
Our study did not show significant changes of the haemodynamic parameters during the treatment of acute liver failure using the Prometheus device in large laboratory animals.
Keywords:
experimental acute liver failure – fractioned plasmatic separation and adsorption – haemodynamic parameters
Zdroje
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Štítky
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineČlánok vyšiel v časopise
Anaesthesiology and Intensive Care Medicine
2010 Číslo 4
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