New biomarkers in the diagnosis of renal dysfunction
Authors:
Gerlichová Monika 1; Živný Pavel 2; Matějovič Martin 3; Černý Vladimír 1
Authors place of work:
Klinika anesteziologie, resuscitace a intenzivní medicíny, Univerzita Karlova v Praze, LF v Hradci Králové a Fakultní nemocnice Hradec Králové
1; Ústav klinické biochemie a diagnostiky, Univerzita Karlova v Praze, LF v Hradci Králové a Fakultní nemocnice Hradec Králové
2; I. interní klinika – JIP, Univerzita Karlova v Praze, LF v Plzni, Fakultní nemocnice Plzeň
3
Published in the journal:
Anest. intenziv. Med., 22, 2011, č. 1, s. 23-27
Category:
Intensive Care Medicine - Review Article
Summary
The introduction of new preventive and therapeutic interventions in the treatment of acute kidney injury depends on its early diagnosis. For this reason the priority is to search for markers that can indicate renal dysfunction earlier than the reduction in glomerular filtration rate with a subsequent increase in the serum creatinine levels and a decrease in diuresis.
Clinical research in various patient subpopulations (intensive care, cardiac surgery, transplanr surgery) is going on, yet without clear recommendation for clinical practice. Neutrophil gelatinase-associated lipocalin (NGAL) is one the most promising biomarkers of renal injury, detectable in plasma and urine within 2–4 hours after insult. Its good diagnostic and prognostic value was confirmed in meta-analysis of 19 clinical studies including 2 500 patients. NGAL is elevated in various forms of acute and chronic kidney injuries. For this reason, it should be ferther used in combination with other markers (interleukin-18 and kidney injury molecule-1) for more specific diagnosis.
Keywords:
acute kidney injury – tubular damage – early markers of renal dysfunction – neutrophil gelatinase- associated lipocalin – interleukin 18 – kidney injury molecule-1
Zdroje
1. Jo, K. S., Rosner, M. H., Okusa M. D. Pharmacologic Treatment of Acute Kidney Injury: Why Drugs Haven’t Worked and What Is on the Horizon. Clin. J. Am. Soc. Nephrol., 2007, 2, p. 356–365.
2. Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K. et al. Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury. J. Am. Soc. Nephrol., 2003, 14, p. 2534–2543.
3. Nquyen, M. T., Devarajan, P. Biomarkers for the early detection of acute kidney injury. Pediatr. Nephrol., 2008, 23, p. 2151–2157.
4. Grenier, F., Ali, S., Syed, H. et al. Multi-site Evaluation of an Assay in Development for Urine NGAL on the Abbott ARCHITECT Analyzer. American Association of Clinical Chemists Annual Meeting, Washington, DC, July 27–31, 2008 (abstract).
5. Mishra, J., Dent, C., Tarabishi, R. et al. Neutrophil gelatinase-associated lipocalin as a biomarker for acute renal injury after cardiac surgery. The Lancet, 2005, 365, 9466, p. 1231–1238.
6. Dent, C. L., Ma, Q., Dastrala, S. et al. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit. Care, 2007. Dostupný na www: http://ccforum.com/content/11/6/R127.
7. Wagener, G., Jan, M., Kim, M. et al. Association between Increases in Urinary Neutrophil Gelatinase-associated Lipocalin and Acute Renal Dysfunction after Adult Cardiac Surgery. Anestesiology, 2006, 105, p. 485–491.
8. Tuladhar, S. M., Puntmann, V. O., Soni, M. et al. Rapid Detection of Acute Kidney Injury by Plasma and Urinary Neutrophil Gelatinase-associated Lipocalin after Cardiopulmonary Bypass. J. Cardiovasc. Pharmacol., 2009, 53, 3, p. 261–266.
9. Wagener, G., Gubitosa, G., Wang, S. et al. Urinary Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury After Cardiac Surgery. Am. J. Kidney Diseases, 2008, 52, 3, p. 425–433.
10. Mishra, J., Ma, Q., Kelly, C. et al. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr. Nephrol., 2006, 21, p. 856–863.
11. Bachorzewska-Gajewska, H., Malyszko, J., Sitniewska, E. et al. Neutrophil gelatinaseassociated lipocalin and renal function after percutaneous coronary interventions. Am. J. Nephrol., 2006, 6, p. 1639–1645.
12. Cruz, D. N., Cal, M., Garzotto, F. et al. Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med., 2010, 36, p. 444–451.
13. Bagshaw, S. M., Bennett, M., Haase, M. et al. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med., 2010, 36, p. 452–461.
14. Haase, M., Bellomo, R., Devarajan, P. et al. Accuracy of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Diagnosis and Prognosis in Acute Kidney Injury: A Systematic Review and Meta-analysis. Am. J. Kidney Diseases, 2009, 54, 6, p. 1012–1024.
15. Mori, K., Lee, H. T., Rapoport, D. et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Investig., 2005, 115, 3, p. 610–621.
16. Bagshaw, S. M., Gibney, R. T. N. Conventional markers of kidney function. Crit. Care Med., 2008, 36, 4 suppl., p. 152–158.
17. Bokenhamp, A., Laarman, C., Braam, K. I. et al. Effect of Corticosteroid Therapy on Low-Molecular-Weight Protein Markers of Kidney Function. Clin. Chemistry, 2007, 53, p. 2219–2221.
18. Hollander, J. G., Wulkan, R. W. et al. Is Cystatin C a Marker of Glomerular Filtration Rate in Thyroid Dysfunction? Clin. Chemistry, 2003, 49, p. 1558–1559.
19. Vaidya, V. S., Waikar, S. S., Ferguson, M. A. et al. Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans. Clin. Transl. Sci., 2008, 1, 3, p. 200–208.
20. Reese, P. P., Feldman, H. I. More Evidence that Cystatin C Predicts Mortality Better than Creatinine. J. Am. Soc. Nephrol., 2009, 20, p. 2088–2090.
21. VandeVoorde, R. G., Katman, T. I., Ma, Q. et al. Serum NGAL and Cystatin C as predictive biomarkers for acute kidney injury. J. Am. Soc. Nephrol., 2006, 17, 404 abstr.
22. Soto, K., Coelho, S., Rodriques, B. et al. Cystatin C as a Marker of Acute Kidney Injury in the Emergency Department. Clin. J. Am. Soc. Nephrol., 2010, epub ahead of print.
23. Bagshaw, S. M., Bellomo, R. Early diagnosis of acute kidney injury. Cur. Opin. Crit. Care, 2007, 13, p. 638–644.
24. Parikh, C. R., Abraham, E., Ancukiewicz. M., Edelstein. C. L. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J. Am. Soc. Nephrol., 2005, 16, p. 3046–3052.
25. Liangos, O., Perianayagam, M. C., Vaidya, V. S. et al. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J. Am. Soc. Nephrol., 2007, 18, p. 904–912.
26. Ferguson, M. A., Vaidya, V. S., Bonventre, J. V. Biomarkers of nephrotoxic acute kidney injury. Toxicology, 2008, 245, p. 182–193.
27. Han, W. K., Bonventre, J. V. Biologic markers for the early detection of acute kidney injury. Curr. Opin. Crit. Care, 2004, 10, p. 476–482.
28. Negishi, K., Noiri, E., Doi, K. et al. Monitoring of Urinary L-Type Fatty Acid-Binding Protein Predicts Histological Severity of Acute Kidney Injury. Am. J. Pathol., 2009, 174, 4, p. 1154–1159.
29. Ferguson, M. A., Vaidya, V. S., Waikar, S. S. et al. Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int., 2009. Dostupný na www: http://www.nature.com/ki/index.html (10.1038/ki.2009.422).
30. Portilla, D., Dent. C., Sugaya. T. et al. Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int., 2008, 73, 4, p. 465–472.
31. Zhou, H., Pisitkun, T., Aponte, A. et al. Exosomal Fetuin-A identified by proteomics: a novel urinary biomarler for detecting acute kidney injury. Kidney Int., 2006, 70, 10, p. 1847–1857.
Štítky
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineČlánok vyšiel v časopise
Anaesthesiology and Intensive Care Medicine
2011 Číslo 1
Najčítanejšie v tomto čísle
- Classification and diagnosis of kidney injury – are they still imperfect?
- The administration of packed red blood cells and its influence on electrolyte and acid-base balance disturbances in vivo
- Evolution of Anaesthesiology and Resuscitation at Prague’s Medical Faculties
- New biomarkers in the diagnosis of renal dysfunction