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The 2016 definition of sepsis (Sepsis-3)


Authors: P. Sklienka 1,3;  J. Beneš 2;  J. Máca 1,3
Authors place of work: Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Ostrava 1;  Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Plzeň Lékařská fakulta v Plzni, Univerzita Karlova Praha 2;  Lékařská fakulta, Ostravská univerzita v Ostravě 3
Published in the journal: Anest. intenziv. Med., 27, 2016, č. 5, s. 302-308
Category: Intensive Care Medicine - Review Article

Summary

Sepsis represents a life-threatening condition characterized by dysregulated host response to infection. Various definitions and criteria for sepsis, severe sepsis, septic shock and organ dysfunction were used in the past, giving rise to contradictions in the results of the reported data regarding sepsis. Recently, „The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)“ created by the task force of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine was published in 2016.

Keywords:
sepsis – septic shock – organ dysfunction – definition – criteria


Zdroje

1. Singer, M., Deutschman, C. S., Seymour, C. W. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 315, 8, p. 801–810.

2. Mayr, F. B., Yende, S., Angus, D. C. Epidemiology of severe sepsis. Virulence, 2014, 5, 1, p. 4–11.

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8. Abraham, E. New Definitions for Sepsis and Septic Shock: Continuing Evolution but With Much Still to Be Done. JAMA, 2016, 315, 8, p. 757–759.

9. Bone, R. C., Balk, R. A., Cerra, F. B. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101, p. 1644–1655.

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11. Kaukonen, K. M., Bailey, M., Pilcher, D. et al. Systemic inflam-matory response syndrome criteria in defining severe sepsis. N. Engl. J. Med., 2015, 372, p. 1629–1638.

12. Levy, M. M., Fink, M. P., Marshall, J. C. et al. 2001 SCCM/ ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med., 2003, 31, p. 1250–1256.

13. Rhee, C., Kadri, S. S., Danner, R. L. et al. Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit. Care, 2016, 20, 1, p. 89.

14. Seymour, C. W., Coopersmith, C. M., Deutschman, C. S. et al. Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria. Crit. Care Med., 2016, 44, 3, p. e122–130.

15. Surviving Sepsis Campaign Responds to Sepsis-3. Dostupné na www: http://www.survivingsepsis.org/SiteCollectionDocuments/SSC-Statements-Sepsis-Definitions-3-2016.pdf.

Štítky
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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