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Thrombophilic conditions during pregnancy


Authors: J. Mannová 1;  M. Penka 2;  P. Štourač 3
Authors place of work: Anesteziologicko-resuscitační oddělení, Nemocnice Havlíčkův Brod 1;  Oddělení klinické hematologie, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno 2;  Klinika dětské anesteziologie a resuscitace, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno 3
Published in the journal: Anest. intenziv. Med., 27, 2016, č. 6, s. 380-389
Category:

Summary

The risk of venous thromboembolic events is high during pregnancy due to both the physiologic changes of pregnancy and the additional impact of inherited or acquired thrombophilias. The women with thrombophilia are at increased risk not only of pregnancy-related venous thromboembolism (VTE), but also other pregnancy-related complications, including early and late miscarriage, intrauterine growth retardation, placental abruption and pre-eclampsia. Depending on the type of thrombophilia, personal and family history of VTE and history of complications during pregnancy, prophylactic treatment with low molecular weight heparin or unfractionated heparin is recommended. For women with thrombophilia and history of complications during pregnancy, a combination of low dose aspirin and heparin can increase the probability of live birth. On the other hand, pregnant women on prophylactic or therapeutic anticoagulation require individualized delivery plans addressing the obstetric, anaesthetic and thrombotic concerns.

Keywords:
pregnancy – thrombophilia – prophylaxis – anaesthetic management


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Štítky
Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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