Cardiovascular safety of tocilizumab therapy: results of the ENTRACTE Clinical Trial
Authors:
Heřman Mann
Authors place of work:
Revmatologická klinika 1. LF UK a Revmatologický ústav, Praha
Published in the journal:
AtheroRev 2018; 3(2): 101-105
Category:
clinical studies
Summary
Rheumatoid arthritis is associated with an increased risk of cardiovascular disease, due to chronic inflammation in addition to other typical risk factors. A so-called lipid paradox has been described in patients with rheumatoid arthritis, a situation in which inflammation induces a decrease and successful anti-inflammatory treatment is associated with an increase in serum lipid levels. Suppression of inflammatory activity by methotrexate or biological agents leads to a reduction of cardiovascular disease risk. During treatment with tocilizumab, there is a more significant increase in cholesterol levels compared with treatment with tumor necrosis factor-blockers. Changes in the lipid levels usually occur within the first weeks of treatment with tocilizumab and stabilize thereafter. Analysis of available data and the results of ENTRACTE trial failed to show an increased risk of cardiovascular events associated with tocilizumab compared to other biologics.
Key words:
cardiovascular risk, lipidogram, rheumatoid arthritis, tocilizumab
Zdroje
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Štítky
Angiology Diabetology Internal medicine Cardiology General practitioner for adultsČlánok vyšiel v časopise
Athero Review
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