Hypolipidemic treatment and microvascular complications of diabetes

Česká verzia

Authors: Branislav Vohnout ^1,2,3,5; Jana Lisičanová ³; Andrea Havranová ⁴
Authors place of work: Ústav výživy, Fakulta ošetrovateľstva a zdravotníckych odborných štúdií, SZU v Bratislave ¹; Ústav epidemiológie LF UK, Bratislava ²; Ambulancia diabetológie a porúch látkovej premeny a výživa, Diabeda s. r. o., Bratislava ³; Ústav klinického a translačného výskumu – Biomedicínske centrum SAV, Bratislava ⁴; Koordinačné centrum pre familiárne hyperlipoproteinémie, SZU v Bratislave ⁵
Published in the journal: AtheroRev 2019; 4(2): 95-99
Category: Reviews

Summary

Diabetes mellitus (DM) is associated with an increased risk of developing micro- and macrovascular complications. One of the factors that may be involved in the onset and progression of microvascular impairment is dyslipidemia. While the effect of dyslipidemia and its treatment on cardiovascular risk in patients is well known, the effect of hypolipidemic treatment on microvascular complications is not so clear. Although some studies suggest a possible effect of statins on some microvascular complications, these data are often contradictory, and the positive effect of statins on microvascular complications has not been demonstrated. On the other hand, the results of clinical trials show the promising effect of fibrates on the progression of microvascular complications of diabetes. Within the FIELD and ACCORD studies, treatment with fenofibrate led to a slowdown in the progression of diabetic retinopathy, and in the FIELD study retinal laser treatment was significantly reduced and the number of non-traumatic lower limb amputations decreased. This positive effect is probably due not only to the hypolipidemic but also to other pleiotropic effects of such treatment. The paper presents an overview of the effects of hypolipidemic treatment with respect to influencing the individual microvascular complications of diabetes.

Keywords:

diabetes – fenofibrate – microvascular complications

Zdroje

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