The 95th percentile of LDL-cholesterol in the Czech population: The Czech post- MONICA study

Česká verzia

Authors: Renata Cífková ^1,2; Jan Bruthans ¹; Peter Wohlfahrt ¹; Alena Krajčoviechová ¹; Pavel Šulc ¹; Lenka Eremiášová ²; Jan Pudil ²; Aleš Linhart ²; Jiří Widimský Jr ³; Jan Filipovský ⁴; Otto Mayer Jr ⁴; Věra Lánská ⁵; Rudolf Poledne ⁶; Petr Stávek ⁶; Vladimír Soška ⁷
Authors place of work: Centrum kardiovaskulární prevence 1. LF UK a FTN, Praha ¹; II. interní klinika kardiologie a angiologie 1. LF UK a VFN v Praze ²; III. interní klinika – endokrinologie a metabolismu 1. LF UK a VFN v Praze ³; II. interní klinika LF UK a FN Plzeň ⁴; Oddělení lékařské statistiky IKEM, Praha ⁵; Centrum experimentální medicíny, Laboratoř pro výzkum aterosklerózy IKEM, Praha ⁶; Oddělení klinické biochemie FN U sv. Anny v Brně ⁷
Published in the journal: AtheroRev 2023; 8(1): 7-10
Category: Clinical Studies

Summary

According to the latest statistical data to date, cardiovascular disease (CVD) is the leading cause of death in the Czech Republic, accounting for 36.5% of deaths in men and 43.1% of deaths in women. According to data from the World Health Organization and the European Society of Cardiology, the Czech Republic is one of the countries with a high mortality rate from CVD. The main risk factors for CVD include dyslipidemia, LDL-cholesterol (LDL-C) has been identified as a major determinant of the risk for developing atherosclerosis. The aim of this analysis of the Czech post-MONICA study was to determine the 95th percentile values for LDL-C in a representative sample of the Czech population examined in 2015–2018. The 95th percentile values of LDL-C by age and sex are required to determine the probability of FH according to the Dutch Lipid Network Criteria.

Keywords:

cardiovascular disease – cardiovascular risk factors – Dutch Lipid Network Criteria – familiar hypercholesterolemia –population random sample

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