Positive association of adiponectin with adipocyte fatty acid binding protein in patients with unfavourable dyslipidemic phenotype
Authors:
D. Novotný 1; H. Vaverková 2; D. Karásek 2; M. Bartková 1; J. Lukeš 1
Authors place of work:
Oddělení klinické biochemie, Fakultní nemocnice Olomouc, I. P. Pavlova 6, 775 0 Olomouc, Česká republika
1; III. Interní klinika Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc, I. P. Pavlova 6, 775 20 Olomouc, Česká republika
2
Published in the journal:
Klin. Biochem. Metab., 22 (43), 2014, No. 3, p. 116-122
Summary
Objective:
We examined 214 asymptomatic dyslipidemic individuals divided into two groups, DLP1 (n = 66) and DLP2 (n = 148), according to triglyceride (TG) and apolipoprotein B (Apo B) levels. The aim of our study was to evaluate the relationship of adiponectin (ADP) with adipocyte fatty acid binding protein (A-FABP), and to elucidate possible associations to lipid parameters, markers of insulin resistance and endothelial haemostatic markers in observed groups.
Design:
prospective observational
Results:
In DLP2 group (TG ≥ 1.5 mmol and/or Apo B ≥ 1.2 g/l), we found the positive correlations of ADP with age, HDL cholesterol, apolipoprotein A1, N-terminal prohormone of brain natriuretic peptide, von Willebrand factor and A-FABP, and the negative correlation with body mass index, waist circumference, TG, atherogenic index of plasma, insulin, C-peptide and proinsulin. In the same group, the significant positive correlations of A-FABP with age, body mass index, waist circumference, C- reactive protein, N-terminal prohormone of brain natriuretic peptide, von Willebrand factor, plasminogen activator inhibitor-1, C-peptide, proinsulin and ADP were observed. The multiple regression analysis with adipokines as dependent variables and correlated parameters as independent predictors revealed the independent positive relationship of ADP with age (beta = 0.3764, p<0.0080) and A-FABP (beta = 0.2062, p = 0.0111). In DLP2 group, we also found the independent positive association of A-FABP with body mass index (beta = 1.0375, p = 0.0107) and ADP (beta = 0.2322, p = 0.0088), in contrast to DLP1 group.
Conclusion:
The independent positive reciprocal association of ADP with A-FABP in subjects with unfavourable dyslipidemic phenotype could be related to the higher cardiovascular risk.
Keywords:
dyslipidemia, adipokines, adiponectin, adipocyte fatty acid binding protein, von Willebrand factor
Zdroje
1. Funahashi, T., Nakamura, T., Shimomura, I. et al. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern. Med.,1999, 38, p. 202-206.
2. Libby, P., Okamoto, Y., Rocha, V. Z., Folco, E. Inflammation in atherosclerosis: transition from theory to practice. Circ. J., 2011, 74, p. 213-220.
3. Shimada, K., Miyazaki, T., Hiroyuki, D. Adiponectin and atherosclerotic disease. Clin . Chim. Acta, 2004, 344, p. 1-12.
4. Ouchi, N., Walsh, K. Adiponectin as an anti-inflammatory factor. Clin. Chim. Acta, 2007, 380, p. 24-30.
5. Peake, P. W. , Shen, Y., Walther, A. et al. Adiponectin binds C1q and activates the classical pathway of complement. Biochem. Biophys. Res. Commun., 2008, 367, p. 560-565.
6. Saely, Ch. H., Risch, L., Hoefle, G. et al. Low serum adiponectin is independently associated with both the metabolic syndrome and angiographically determined coronary atherosclerosis. Clin. Chim. Acta, 2007, 383, p. 97-102.
7. Xu, A., Wang, Y., Xu, J. Y. et al. Adipocyte fatty acid binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin. Chem., 2006, 52, p. 405-413.
8. Sniderman, A. D. Applying apo B to the diagnosis and therapy of the atherogenic dyslipoproteinemias: a clinical diagnostic algorythm. Curr. Opin. Lipidol., 2004,15, p. 433-438.
9. Catapano A. L., Reiner Ž., De Backer G. et al. ESC/EAS Guidelines for the management of dyslipidaemias. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis, 2011, 217S, s. S1-S44.
10. Kathiresan, S., Otvos, J. D., Sullivan, L. M. et al. Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Fra-mingham Heart Study. Circulation, 2006, 113, p. 20-29.
11. Rizzo, M., Berneis, K. Small, dense low-density-lipoproteins and the metabolic syndrome. Diabetes Metab. Res. Rev., 2007, 23, p. 14-20.
12. Griffin, B. A., Freeman, D. J., Tait, G. W. et al. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis, 1994, 106, p. 241-253.
13. Talmud, P. J., Hawe, E., Miller, G. J., Humphries, S. E. Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men. Arterioscler. Thromb. Vasc. Biol., 2002, 22, p. 1918-1923.
14. Vaverkova, H., Karasek, D., Novotny, D. et al. Apolipoprotein B versus LDL-cholesterol: association with other risk factors for atherosclerosis. Clin. Biochem., 2009, 42, p.1246-1251.
15. Park, S. E., Rhee, E. J., Lee, W. Y. et al. The role of serum adipocyte fatty acid-binding protein on the deve-lopment of metabolic syndrome is independent of pro-inflammatory cytokines. Nutr. Metab. Cardiovascular. Dis., 2012, 22, p. 525-532.
16. Vaverkova, H., Karasek, D., Novotny, D. et al. Positive association of adiponectin with soluble thrombomodulin, von Willebrand factor and soluble VCAM-1 in dyslipidemic subjects. Clin. Biochem., 2013, 46, p. 766-771.
17. Whincup, P. H., Danesh, J., Walker, M. et al. von Willebrand factor and coronary heart disease. Prospective study and meta-analysis. Eur. Heart J., 2002, 23, p. 1764-1770.
18. Spiel, A. O., Gilbert, J. C., Jilma, B. von Willebrand factor in cardiovascular disease. Focus on Acute Coronary Syndromes. Circulation, 2008, 117, p. 1449-59.
19. Karásek, D., Vaverková, H., Halenka, M. et al. Endothelial haemostatic markers in members of families with familial combined hyperlipidemia. Thromb. Res., 2009, 123, p. 466-475.
20. Xu, A., Vanhoutte, P. M. Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am. J. Physiol. Heart Circ. Physiol., 2012, 302, p. H1231-H1243.
21. Tao, L., Gao, E., Jiao, X., et al. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrosative stress. Circulation, 2007, 115, p. 1408-1416.
22. Frystyk, L., Berne, C., Berglund, L., Jensevik, K., Flyvbjerk, A., Zethelius, B. Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men. J. Clin. Endocrinol. Metab., 2007, 92, p. 571-576.
23. Lindsay, R. S., Resnick, H. E., Zhu, J. et al. Adiponectin and coronary heart disease: the Strong Heart Study. Arterioscler. Thromb. Vasc. Biol., 2005, 25, p. e15-e16. doi: 10.1161/01.ATV.0000153090.21990.
24. Hoo, R. C., Yeung, C. Y., Lam, K. S., Xu, A. Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid-binding protein. Expert Rev. Endocrinol. Metab., 2008, 3, p. 29-41.
25. Furunahashi, M., Hotamisligil, G. S. Fatty acid-binding proteins: role in metabolic diseases and potential as a drug targets. Nat. Rev. Drug Discover., 2008, 7, p. 489-503.
26. Lamounier-Zepter, V., Look, C., Alvarez, J. et al. Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ. Res., 2009, 105, p. 326-334.
27. Von Eynatten, M., Hamann, A., Twardella, D., Nawroth, P. P., Brenner, H., Rothenbacher, D. Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. Clin. Chem., 2006, 52, p. 853-859.
28. Miyoshi, T., Onoue, G., Hirohata, A. et al. Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound. Atherosclerosis, 2010, 211, p.164-169.
29. Rhee, J., Lee, W. Y., Park, C. Y., et al. The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur. J. Endocrinol., 2009, 160, p. 165-172.
30. Zhou, M. I., Bao, Y., Lu, J., Zhou, J., Jia, W. Serum A-FABP is increased and closely associated with elevated NT-proBNP levels in type 2 diabetic patients treated with rosiglitazone. PLoS ONE, 2011, 6, e27032. doi:10.1371/journal.pone.0027032.
31. Novotny, D., Vaverkova, H., Karasek, D. et al. Evaluation of total adiponectin, adipocyte fatty acid binding protein and fibroblast growth factor 21 levels in individuals with metabolic syndrome. Physiol. Res., 2014, 63, p. 219-228.
Štítky
Clinical biochemistry Nuclear medicine Nutritive therapistČlánok vyšiel v časopise
Clinical Biochemistry and Metabolism
2014 Číslo 3
Najčítanejšie v tomto čísle
- Comparison of creatinine clearance and estimated glomerular filtration rate in patients with chronic kidney disease
- Unification and validation of reference intervals – pilot study
- Quality requirements for the determination of glycated hemoglobin HbA1c and possibilities of its application for diagnostic purposes
- Positive association of adiponectin with adipocyte fatty acid binding protein in patients with unfavourable dyslipidemic phenotype