Metastatic choriocarcinoma in 26-year-old woman – case report

Česká verzia

Authors: M. Bôžik
Authors place of work: RDG oddelenie, Fakultná nemocnica Trenčín, Slovenská republika
Published in the journal: Klin Onkol 2011; 24(2): 137-142
Category: Case Reports

Summary

Gestational trophoblastic tumors are a group of diseases spanning from a benign hydatidiform mole, through an invasive mole to a highly malignant form of choriocarcinoma. Choriocarcinoma is a rare but the most malignant and aggressive neoplasm of all the gestational trophoblastic diseases. It grows rapidly and metastasizes into the lungs, liver, and, less frequently, to the brain. The author presents a case of a 26-year-old woman who was, based on previous investigations, referred for a CT examination for suspected brain tumour. On the basis of medical history provided by the patient‘s husband, high ß-hCG level and a gynaecological examination, the patient was diagnosed with choriocarcinoma metastasizing into the brain, kidneys and adrenal glands.

Key words:
choriocarcinoma – trophoblastic neoplasms – metastases – computed tomography

Zdroje

1. Korbeľ M, Nižňanská Z, Šufliarsky J et al. Gravidita po liečbe gestačnej trofoblastovej choroby. Gynekol Prax 2010; 8(3): 141–145.

2. Danihel Ľ, Černá A, Šišovský V et al. Súčasná klasifikácia a morfologická charakteristika nádorov trofoblastu. Onkológia (Bratisl.) 2008; 3(4): 230–232.

3. Repiská V, Vojtaššák J, Böhmer D et al. Algoritmus diferenciálnej diagnostiky gestačnej trofoblastovej choroby. Prakt Gynek 2009; 16(1): 15–18.

4. Šufliarsky J, Korbeľ M, Ilavská I et al. Klinická klasifikácia a liečba malígnych foriem gestačnej trofoblastovej choroby. Slov Gynek Pôrod 2003; 10(2): 95–99.

5. Danihel Ľ, Korbeľ M, Palkovič M et al. Súčasný pohľad na klasifikáciu gestačnej trofoblastovej choroby a charakteristika základných foriem. Slov Gynek Pôrod 2003; 10(2): 75–80.

6. Ježová M, Hotárková S, Múčková K et al. Fetopatologie a vývojová patologie embrya a plodu. Hypertextový atlas fetální patologie [cited 2010 September]. Dostupné z: http://atlases.muni.cz/atlases/feto/atl_cz/main+fetopatologie+patolplac.html#gesttrofoblnemoc+molahyd_id_221.

7. Rob L. Gestační trofoblastická nemoc. Česká onkologická společnost ČLS JEP [cited 2007 January 4]. Dostupné z: http://www.linkos.cz/pacienti/gyn_clanek4.php#6.

8. Sierra-Bergua B, Sánchez-Marteles M, Cabrerizo-García JL et al. Choriocarcinoma with pulmonary and cerebral metastases. Singapore Med J 2008; 49(10): e268–e288.

9. Lee JH, Park CW, Chung DH et al. A case of lumbar metastasis of choriocarcinoma masqueranding as an extraosseous extension of vertebral hemangioma. J Korean Neurosurg Soc 2010; 47(2): 143–147.

10. Zairi F, De Saint Denis T, Thines L et al. Ruptured cerebral oncotic aneurysm from choriocarcinoma: report of two cases and review of the literature. Acta Neurochir (Wien) 2011; 153(2): 353–357.

11. Singhal M, Kudesia S, Bhat K et al. Spontaneous intracerebral haemorrhage as initial presentation of gestational choriocarcinoma in a young woman: a case report and review of literature. Int J Pathol 2010; 10(2).

12. Tasdemir Serhan M, Aktas A, Tasdemir N et al. Gingival metastase and intracerebral haemorrhage resulting from unsuspected choriocarcinoma: a case report. J Int Dent Med Res 2010; 3(2): 79–81.

13. Rocque G B, Baskaya KM. Spontaneous acute subdural hematoma as an initial presentation of choriocarcinoma: A case report. J Med Case Rep 2008. Available from: http://www.jmedicalcasereports.com/content/2/1/211.

14. Chang IB, Cho BM, Park SH et al. Metastatic choriocarcinoma with multiple neoplastic intracranial microaneurysms: case report. J Neurosurg 2008; 108(5): 1014–1017.

15. Suresh TN, Santosh V, Shastry Kolluri VR et al. Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis. Neurol India 2001; 49(3): 231–236.

16. Ilavská I, Korbeľ M, Šufliarsky J et al. Výsledky liečby malígnych foriem gestačnej trofoblastovej choroby v Slovenskej republike. Slov Gynek Pôrod 2003; 10: 70–74.

17. Korbeľ M, Danihel Ľ, Vojtaššák J et al. Centrum pre trofoblastovú chorobu Slovenskej republiky – 15 rokov činnosti. Slov Gynek Pôrod 2010; 17: 129–132.

18. Hashemi Amouzegar F, Ghaemmaghami F, Behtash N. Unusual presentation of gestational neoplasm: Report of two cases. Iran J Radiat Res 2006; 3(4): 199–202.

19. Semple LP, Denny L, Coughlan M et al. The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases. Int J Gynecol Cancer 2004; 14(1): 157–161.

20. Bilgin T, Ozan H, Ozuysal S et al. Successful salvage therapy of resistant gestational trophoblastic disease with etoposide, methotrexate, actinomycin-D, etoposide, cisplatin (EMA/EP). Arch Gynecol Obstet 2004; 269(2): 159–160.