Dental Abnormalities after Treatment for Childhood Cancer
Authors:
B. Mladosievičová 1; R. Jurkovič 2; L. Izakovičová Hollá 3,4
Authors place of work:
Oddelenie klinickej patofyziológie, LF UK Bratislava, Slovenská republika
1; DEIMPERIO, spol. s r. o., Bratislava, Slovenská republika
2; Stomatologická klinika LF MU a FN u sv. Anny v Brně
3; Ústav patologické fyziologie, LF MU, Brno
4
Published in the journal:
Klin Onkol 2015; 28(1): 20-23
Category:
Review
doi:
https://doi.org/10.14735/amko201520
Summary
Childhood cancer therapy often increases the risk of dental complications, such as tooth and roots agenesis, microdontia, abnormal development of tooth enamel, increased risk of cavity and other abnormalities. In a comparison with other late adverse effects of chemotherapy, radiotherapy and hematopoietic stem cell transplantion, a relative small number of clinical studies observing patients for more than two years after completion of anticancer treatment was published. In this article, we review the incidence of dental abnormalities caused by commonly used anticancer treatment modalities as well as discuss their risk factors. Early identification of high-risk patients, early detection and management of dental abnormalities and better education of patients or their guardians, may have an impact on quality of life of cancer survivors.
Key words:
chemotherapy – radiotherapy – late effects – tooth abnormalities – childhood cancer
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
3. 3. 2014
Accepted:
4. 12. 2014
Zdroje
1. Kepák T, Radvanská J, Bajčiová V et al. Long term survivors of childhood cancer: cure and care. The ERICE statement. Klin Onkol 2009; 22(2): 77– 79.
2. Gawade PL, Hudson MM, Kaste SC et al. A systematic review of dental late effects in survivors of childhood cancer. Pediatr Blood Cancer 2014; 61(3): 407– 416. doi: 10.1002/ pbc.24842.
3. Dahllőf G. Oral dental late effects after pediatric stem cell transplantation. Biol Blood Marrow Transplant 2008; 14 (Suppl 1): 81– 83. doi: 10.1016/ j.bbmt.2007.11.007.
4. Rowland C, Kaste S, Owens A. Interrupted development of dentition in children receiving bone marrow transplantation for acute lymphocytic leukemia: a case series. Spec Care Dentist 2013; 33(6): 308– 311. doi: 10.1111/ j.1754‑ 4505.2012.00315.x.
5. Oğuz A, Cetiner S, Karadeniz C et al. Long‑term effects of chemotherapy on orodental structures in children with non‑Hodgkin‘s lymphoma. Eur J Oral Sci 2004; 112(1): 8– 11.
6. Hong CH, Napenas JJ, Hodgson BD et al. A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer 2010; 18(8): 1007– 1021. doi: 10.1007/ s00520‑ 010‑ 0873‑ 2.
7. Nishimura S, Inada H, Sawa, Y et al. Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers. Eur J Cancer Care 2013; 22(3): 353– 360. doi: 10.1111/ ecc.12038.
8. Pedersen LB, Clausen N, Schrøder H et al. Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent 2012; 22(4): 239– 243. doi: 10.1111/ j.1365‑ 263X.2011.01199.x.
9. Kaste SC, Goodman P, Leisenring W et al. Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study. Cancer 2009; 115(24): 5817– 5827. doi: 10.1002/ cncr.24670.
10. Hsieh SG, Hibbert S, Shaw P et al. Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy. Cancer 2011; 117(10): 2219– 2227. doi: 10.1002/ cncr.25704.
11. Mladosievičová B, Kaiserová E, Foltínová A (eds). Možné neskoré následky protinádorovej liečby v detstve. Bratislava: SAP 2007: 212.
12. Lyaruu DM, van Duin MA, Bervoets TJ et al. Effects of actinomycin D on developing hamster molar tooth germs in vitro. Eur J Oral Sci 1997; 105(1): 52– 58.
13. Karim AC, Woltgens JH, Bervoets TJ et al. Effect of Adriamycin on hamster molar tooth development in vitro: 1. Morphological changes. Anat Rec 1989; 225(4): 318– 328.
14. Lyaruu DM, van Duin MA, Bervoets TJ et al. Daunorubicin‑induced pathology in the developing hamster molar tooth germ in vitro. Cancer Detect Prev 1999; 23(4): 343– 350.
15. Anton E. Ultrastructural study of the effect of cyclophosphamide on the growth area of incisor teeth of DBA/ 2 and C57BL/ 6 mice. Int J Exp Pathol 1996; 77(2): 83– 88.
16. Näsman M, Hammarstrom L. Influence of the antineoplastic agent cyclophosphamide on dental development in rat molars. Acta Odontol Scand 1996; 54(5): 287– 294.
17. Wogelius P, Dahllof G, Gorst‑ Rasmussen A et al. A population‑based observational study of dental caries among survivors of childhood cancer. Pediatr Blood Cancer 2008; 50(6): 1221– 1226. doi: 10.1002/ pbc.21464.
18. Maeda S, Suda M, Ishii M et al. Extreme tooth abnormalities and treatment under general anesthesia in a child with chronic GVHD surviving relapse of acute lymphoblastic leukemia. J Clin Pediatr Dent 2012; 37(2): 199– 201.
19. Nemeth O, Hermann P, Kivovics P et al. Long‑term effects of chemotherapy on dental status of children cancer survivors. Pediatr Hematol Oncol 2013; 30(3): 208– 215. doi: 10.3109/ 08880018.2013.763391.
20. Duggal MS, Curzon ME, Bailey CC et al. Dental parameters in the long‑term survivors of childhood cancer compared with siblings. Oral Oncol 1997; 33(5): 348– 353.
21. Pajari U, Yliniemi R, Möttönen M. The risk of dental caries in childhood cancer is not high if the teeth are caries‑free at diagnosis. Pediatr Hematol Oncol 2001; 18(3): 181– 185.
22. Jones LR, Toth BB, Keene HJ. Effects of total body irradiation on salivary gland function and caries associated oral microflora in bone marrow transplant patients. Oral Surg Oral Med Oral Pathol 1992; 73(6): 670– 676.
23. Dahllőf G, Bagesund M, Ringden O. Impact of conditioning regimens on salivary function, caries associated microorganisms and dental caries in children after bone marrow transplantation. A 4‑year longitudinal study. Bone Marrow Transplant 1997; 20(6): 479– 483.
24. Jensen SB, Pedersen AM, Vissink A et al. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life. Support Care Cancer 2010; 18(8): 1039– 1060. doi: 10.1007/ s00520‑ 010‑ 0827‑ 8.
25. Faraci M, Békássy AN, De Fazio et al. Non‑ endocrine late complications in children after allogeneic haematopoietic SCT. Bone Marrow Transplant 2008; 41 (Suppl 2): S49– S57. doi: 10.1038/ bmt.2008.55.
26. Sonis AL, Tarbell N, Valachovic RW et al. Dentofacial development in long‑term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer 1990; 66(12): 2645– 2652.
27. Cubukcu CE, Sevinir B, Ercan I. Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer 2012; 58(1): 80– 84. doi: 10.1002/ pbc.22902.
28. Hölttä P, Alaluusua S, Saarinen‑ Pihkala UM et al. Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer 2005; 103(1): 181– 190.
29. van der Pas‑ van Voskuilen IG, Veerkamp JS et al. Long‑term adverse effects of hematopoietic stem cell transplantation on dental development in children. Support Care Cancer 2009; 17(9): 1169– 1175. doi: 10.1007/ s00520‑ 008‑ 0567‑ 1.
30. Hölttä P, Hovi L, Saarinen‑ Pihkala UM et al. Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Cancer 2005; 103(7): 1484– 1493.
31. Odporúčania Children’s Oncology Group: Dental health following childhood cancer treatment. Available from: http:/ / www.survivorshipguidelines.org/ pdf/ healthlinks/ English/ dental_health_Eng.pdf verzia 4/ 2013.
32. Effinger KE, Migliorati CA, Hudson MM et al. Oral and dental late effects in survivors of childhood cancer: a Children‘s Oncology Group report. Support Care Cancer 2014; 22(7): 2009– 2019. doi: 10.1007/ s00520‑ 014‑ 2260‑ x.
33. Dahllőf G, Huggare J. Orthodontic considerations in the pediatric cancer patient. A review. Semin Orthod 2004; 10(4): 266– 276. doi: 10.1053/ j.sodo.2004.09.007.
34. Dahllőf G, Ulmer M, Jőnsson A et al. Orthodontic therapy in children treated with bone marrow transplantation. Am J Orthod Dentofacial Orthop 2001; 120(5): 459– 465.
Štítky
Paediatric clinical oncology Surgery Clinical oncologyČlánok vyšiel v časopise
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