Vitamin D During Cancer Treatment

Česká verzia

Authors: M. Tomíška ¹; Š. Novotná ¹; L. Klvačová ¹; J. Tůmová ²; A. Janíková ¹
Authors place of work: Interní hematologická a onkologická klinika LF MU a FN Brno ¹; Oddělení klinické biochemie, FN Brno ²
Published in the journal: Klin Onkol 2015; 28(2): 99-104
Category: Review
doi: https://doi.org/10.14735/amko201599

Summary

Recent knowledge on vitamin D has shown that its active form not only regulates calcium and phosphate metabolism but also has significant antimitotic and cell differentiation effects. It can inhibit proliferation, angiogenesis and metastatic potential in cancer tissue. Insufficient vitamin D plasma levels are found in 20– 60% of cancer patients at diagnosis. By many authors, vitamin D deficiency is associated with higher aggressivity of tumor and shorter survival of patients. Even in the absence of clinical studies showing benefit of supplementation on outcome, clear recommendations are currently available for treatment of vitamin D deficiency. Owing to the high prevalence of vitamin D insufficiency in cancer patients and significant risks of its further decrease after antitumor therapy, it should become standard of care to examine 25- hydroxyvitamin D serum levels and correct vitamin D insufficiency in cancer patients.

Key words:
vitamin D deficiency – 25-hydroxyvitamin D – neoplasms – prognosis

This study was supported by the grant for specific research MUNI/A/0723/2012.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
1. 11. 2014

Accepted:
27. 1. 2015

Zdroje

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