Reactive Lymphoid Hyperplasia of the Liver
Authors:
B. Dobiašová; M. Zvaríková; K. Petrakova
Authors place of work:
Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno
Published in the journal:
Klin Onkol 2017; 30(4): 294-298
Category:
Case Report
doi:
https://doi.org/10.14735/amko2017294
Summary
Case:
Here, we present the case of a 50-year-old woman diagnosed with stage I hormone-dependent breast cancer. The patient underwent partial mastectomy followed by adjuvant radiotherapy and hormone treatment with tamoxifen. Three years later, she presented with a solitary liver lesion on MRI, which was highly suspicious of malignancy. However, several fine needle biopsies were performed, and histopathological examination revealed no signs of neoplasia. As a result of these alarming discrepancies, the multidisciplinary board recommended a diag-nostic laparotomy, which yielded a finding consistent with reactive lymphoid hyperplasia, a pseudolymphoma of the liver, on a background of incipient steatohepatitis. This rare condition is characterized by proliferation of non-neoplastic lymphocytes in extranodular sites, and is usually an incidental finding on imaging modalities in clinically asymptomatic patients, predominantly women. Lesions share some radiologic features with primary malignant liver diseases such as hepatocellular carcinoma or cholangiocarcinoma. Although the etiology remains unclear, reactive lymphoid hyperplasia is believed to be associated with some malignancies, including breast cancer, or inflammatory and autoimmune disorders. Reactive lymphoid hyperplasia usually progresses slowly, with some cases of spontaneous regression described in the literature. To the best of our knowledge, only 50 cases of hepatic reactive lymphoid hyperplasia have been reported so far.
Key words:
pseudolymphoma – hyperplasia – liver – lymphatic tissue
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
Submitted:
20. 3. 2017
Accepted:
10. 4. 2017
Zdroje
1. Snover DC, Filipovich AH, Dehner LP et al. ‚Pseudolymphoma‘. A case associated with primary immunodeficiency disease and polyglandular failure syndrome. Arch Pathol Lab Med 1981; 105 (1): 46–49.
2. Yang CT, Liu KL, Lin MC et al. Pseudolymphoma of the liver: report of a case and review of the literature. Asian J Surg 2017; 40 (1): 74–80. doi: 10.1016/j.asjsur.2013.07. 013.
3. Song KD, Jeong WK. Benign nodules mimicking hepatocellular carcinoma on gadoxetic acid-enhanced liver MRI. Clin Mol Hepatol 2015; 21 (2): 187–191. doi: 10.3350/cmh.2015.21.2.187.
4. Lv A, Liu W, Qian HG et al. Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases. Int J Clin Exp Pathol 2015; 8 (5): 5863–5869.
5. Sonomura T, Anami S, Takeuchi T et al. Reactive lymphoid hyperplasia of the liver: Perinodular enhancement on contrast-enhanced computed tomography and magnetic resonance imaging. World J Gastroenterol 2015; 21 (21): 6759–6763. doi: 10.3748/wjg.v21.i21.6759.
6. Machida T, Takahashi T, Itoh T et al. Reactive lymphoid hyperplasia of the liver: a case report and review of literature. World J Gastroenterol 2007; 13 (40): 5403–5407.
7. Knowles DM, Jakobiec FA, McNally L et al. Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. Hum Pathol 1990; 21 (9): 959–973.
8. Abbondanzo SL, Rush W, Bijwaard KE et al. Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases. Am J Surg Pathol 2000; 24 (4): 587–597.
9. Caro WA, Helwig HB. Cutaneous lymphoid hyperplasia. Cancer 1969; 24 (3): 487–502.
10. Baldassano MF, Bailey EM, Ferry JA et al. Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophenotypic features. Am J Surg Pathol 1999; 23 (1): 88–96.
11. Mizukami Y, Ikuta N, Hashimoto T et al. Pseudolymphoma of the thyroid. Acta Pathol Jpn 1988; 38 (10): 1329–1336.
12. Tokunaga O, Watanabe T, Morimatsu M. Pseudolymphoma of the stomach. A clinicopathologic study of 15 cases. Cancer 1987; 59 (7): 1320–1327.
13. Abbondanzo SL, Sobin LH. Gastric „pseudolymphoma“: a retrospective morphologic and immunophenotypic study of 97 cases. Cancer 1997; 79 (9): 1656–1663.
14. Kojima M, Itoh H, Motegi A et al. Localized lymphoid hyperplasia of the rectum resembling polypoid mucosa-associated lymphoid tissue lymphoma: a report of three cases. Pathol Res Pract 2005; 201 (11): 757–761.
15. Nagano K, Fukuda Y, Nakano I et al. Reactive lymphoid hyperplasia of liver coexisting with chronic thyroiditis: radiographical characteristics of the disorder. J Gastroenterol Hepatol 1999; 14 (2): 163–167.
16. Okubo H, Maekawa H, Ogawa K et al. Pseudolymphoma of the liver associated with Sjögren‘s syndrome. Scand J Rheumatol 2001; 30 (2): 117–119.
17. Sharifi S, Murphy M, Loda M et al. Nodular lymphoid lesion of the liver: an immune-mediated disorder mimicking low-grade malignant lymphoma. Am J Surg Pathol 1999; 23 (3): 302–308.
18. Okada T, Mibayashi H, Hasatani K et al. Pseudolymphoma of the liver associated with primary biliary cirrhosis: a case report and review of literature. World J Gastroenterol 2009; 15 (36): 4587–4592.
19. Takahashi H, Sawai H, Matsuo Y et al. Reactive Lymphoid Hyperplasia of the liver in a patient with colon cancer: report of two cases. BMC Gastroenterol 2006; 6: 25.
20. Ohtsu T, Sasaki Y, Tanizaki H et al. Development of pseudolymphoma of liver following interferon-alpha therapy for chronic hepatitis B. Intern Med 1994; 33 (1): 18–22.
21. Kim SR, Hayashi Y, Kang KB et al. A case of pseudolymphoma of the liver with chronic hepatitis C. J Hepatol 1997; 26 (1): 209–214.
22. Saltzstein SL. Pulmonary malignant lymphomas and pseudolymphomas: Classification, therapy, and prognosis. Cancer 1963; 16: 928–955.
23. Katayanagi K, Terada T, Nakanuma Y et al. A case of pseudolymphoma of the liver. Pathol Int 1994; 44 (9): 704–711.
24. Tanizawa T, Eishi Y, Kamiyama R et al. Reactive lymphoid hyperplasia of the liver characterized by an angiofollicular pattern mimicking Castleman‘s disease. Pathol Int 1996; 46 (10): 782–786.
25. Amer A, Mafeld S, Saeed D et al. Reactive lymphoid hyperplasia of the liver and pancreas. A report of two cases and a comprehensive review of the literature. Clin Res Hepatol Gastroenterol 2012; 36 (4): e71–e80. doi: 10.1016/j.clinre.2011.12.004.
26. Yuan L, Zhang Y, Wang Y et al. Reactive lymphoid hyperplasia of the liver: a clinicopathological study of 7 cases. HPB Surg 2012; 2012: 357694. doi: 10.1155/2012/357694.
27. Zen Y, Fujii T, Nakanuma Y. Hepatic pseudolymphoma: a clinicopathological study of five cases and review of the literature. Mod Pathol 2010; 23 (2): 244–250. doi: 10.1038/modpathol.2009.
28. Domínguez-Pérez AD, Castell-Monsalve J. Pseudolymphoma of the liver. Contribution of double-contrast magnetic resonance imaging. Gastroenterol Hepatol 2010; 33 (7): 512–516. doi: 10.1016/j.gastrohep.2010.04. 005.
29. Ota H, Isoda N, Sunada F et al. A case of hepatic pseudolymphoma observed without surgical intervention. Hepat Res 2006; 35 (4): 296–301.
30. Sato SI, Masuda T, Oikawa H et al. Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol 1999; 94 (6): 1669–1673.
31. Koss MN, Hochholzer L, Nichols PW et al. Primary non-Hodgkin‘s lymphoma and pseudolymphoma of lung: a study of 161 patients. Hum Pathol 1983; 14 (12): 1024–1038.
32. Brooks JJ, Enterline HT. Gastric pseudolymphoma. Its three subtypes and relation to lymphoma. Cancer 1983; 51 (3): 476–486.
33. Kulow BF, Cualing H, Steele P et al. Progression of cutaneous B-cell pseudolymphoma to cutaneous B-cell lymphoma. J Cutan Med Surg 2002; 6 (6): 519–528.
Štítky
Paediatric clinical oncology Surgery Clinical oncologyČlánok vyšiel v časopise
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