Biomonitoring of Work with Genotoxic Substances and Factors in a Cancer Treatment Facility

Česká verzia

Authors: M. Petrovová ^1,2; P. Musilová ³; M. Svoboda ^4,5; I. Selingerová ⁶; R. Goněc ^7,8; H. Hradská ³; D. Kadlčíková ³; M. Vozdová ³; P. Brhel ²; J. Rubeš ³
Authors place of work: Ambulance pracovně lékařských služeb, Masarykův onkologický ústav, Brno ¹; Klinika pracovního lékařství LF MU a FN u sv. Anny v Brně ²; Výzkumný ústav veterinárního lékařství, v. v. i., Brno ³; Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno ⁴; Oddělení epidemiologie a genetiky nádorů, Masarykův onkologický ústav, Brno ⁵; Oddělení laboratorní medicíny, Masarykův onkologický ústav, Brno ⁶; Ústavní lékárna, Masarykův onkologický ústav, Brno ⁷; Úsek klinických hodnocení, Masarykův onkologický ústav, Brno ⁸
Published in the journal: Klin Onkol 2018; 31(Supplementum1): 163-167
Category: Article

Summary

Background:
A long-term occupational exposure of healthcare staff to cytostatics and ionizing radiation is associated with a possible manifestation of their genotoxic, carcinogenic and teratogenic effects.

Material and methods:
A total number of 101 employees working with cytostatics or ionizing radiation were examined (some of them repeatedly) in a cancer treatment facility. The control group consisted of 119 persons excluded from the risk exposure. Fluorescence in situ hybridization with three pairs of whole-chromosomal probes and a pancrossomeric probe was used and the translocation frequency was determined.

Results:
The total number of chromosomal rearrangements of healthcare professionals and control group correlates with age. Taking into account the age dependence, an increased level of chromosomal reconstruction was found in the case of 11 individuals, 10 of which were female, working on the positions of pharmacist, general nurse, physician. A total of 9 of those case involved the work with cytostatics. Five of these cases were re-examined two years later and the observed levels dropped to the control level.

Conclusion:
The results of biomonitoring should be evaluated on a group basis and individually, taking into account the personal history and possible non-professional effects on individuals – in particular those related to specific environmental measurement results.

Key words:
preventive medicine – occupational exposure – cytostatic agents – chromosome aberrations – in situ hybridization – fluorescence

The authors declare they have no potential conflicts of interest concern ing drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

This work was supported by project of Ministry of Health Czech Republic. reg. No. 15-33968A.

Submitted:
12. 4. 2018

Accepted:
16. 4. 2018

Zdroje

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