Gastrointestinal Polyposes and Lynch Syndrome – a Pathologist’s Perspective

Česká verzia

Authors: Šárka Pokorová; Pavel Fabian
Authors place of work: Oddělení onkologické patologie, Masarykův onkologický ústav, Brno
Published in the journal: Klin Onkol 2019; 32(Supplementum2): 92-96
Category: Review
doi: https://doi.org/10.14735/amko2019S92

Summary

Gastrointestinal polyposes and Lynch syndrome are a group of heterogenous hereditary tumor syndromes associated with an increased risk of developing colorectal carcinoma and other malignancies. Typical early manifestations of gastrointestinal polyposes include multiple polyps in the gastrointestinal tract. Early recognition of these syndromes enables patients carrying a pathogenic mutation to undergo screening and to instigate precautions to minimize the risk of developing tumors. In some cases, gastrointestinal lesions could be an early indicator of tumor syndrome and histopathologic examination could lead to a recommendation for genetic testing of patients and their families.

Supported by Ministry of Health, Czech Republic – Conceptual Development of Research Organization (MMCI, 00209805).

The authors declare they have no potential conflicts of interest concerning drugs, products,or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted: 16. 4. 2019

Accepted: 6. 6. 2019

Keywords:

Lynch syndrome – gastrointestinal polyposes

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