Future of lung cancer treatment

Česká verzia

Authors: L. Petruželka; J. Špaček; L. Křížová
Authors place of work: Onkologická klinika 1. LF UK a VFN a ÚVN Praha
Published in the journal: Klin Onkol 2021; 34(Supplementum 1): 71-81
Category: Review
doi: https://doi.org/10.48095/ ccko2021S71

Summary

The evolution of lung cancer treatment is an example of new perspectives in clinical oncology. Genomically determined targeted therapy of non-small cell lung cancer (NSCLC) is developing very rapidly with the gradual identification of new target structures and the concomitant development of innovative drugs are a great promise for the future. The historical development of systemic treatment of NSCLC is a model example of the path to accurate (precise) treatment. The innovation of the treatment has led to the shift from (non-targeted) cytostatic treatment to targeted therapy and immunotherapy. The targeted treatment and immunotherapy with checkpoint inhibitors have led to breakthrough prolongation of survival in patients with advanced NSCLC. According to a recent European Society for Medical Oncology (ESMO) recommendation, NSCLC is therefore one of the diagnoses where an examination using the next-generation sequencing panel should be performed as a standard.

Keywords:

precision medicine – personalized medicine – agnostic tumor therapy –next-generation sequencing – checkpoint inhibitors – targeted therapy

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