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preLekára.sk / Journals / Clinical Osteology / 2018 - 4

Clinical perspective of RANK/RANKL/OPG system components in rheumatoid arthritis

Česká verzia

Authors: Gažová Andrea 1;  Kužma Martin 2;  Killinger Zdenko 2;  Payer Juraj 2;  Kyselovič Ján 2
Authors place of work: Ústav farmakológie a klinickej farmakológie, LF UK, Bratislava, Slovensko 1;  V. interná klinika, LF UK a UNB, Nemocnica Ružinov, Bratislava, Slovensko 2
Published in the journal: Clinical Osteology 2018; 23(4): 176-180
Category:

Summary

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease affecting mainly synovial tissue as its primary target. Uncontrolled disease activity causes not only joint destruction but is associated with increased mortality mainly due to cardiovascular involvement. Understanding the role of cytokines in patophysiology of RA and their link to cardiovascular system could contribute to cardiovascular risk markers detection in RA patients.

Keywords:

cardiovascular system – NF-κB signal system – RANK/RANKL/OPG – rheumatoid arthritis

Zdroje
  1. Rochette L, Meloux A, Rigal E et al. The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases. Pharmacol Ther 2018;182:115–132. Dostupné z DOI: <http://doi: 10.1016/j.pharmthera.2017.08.015>.
  2. Masoud S, Lim PB, Kitas GD et al. Sudden cardiac death in patients with rheumatoid arthritis. World J Cardiol 2017; 9(7): 562–573. Dostupné z DOI: <http://doi: 10.4330/wjc.v9.i7.562>.
  3. Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361(21): 2066–2078. Dostupné z DOI: <http://doi: 10.1056/NEJMra0804647>.
  4. Wallace KL, Zheng LB, Kanazawa Y et al. Immunopathology of inflammatory bowel disease. World J Gastroenterol 2014; 20(1): 6–21. Dostupné z DOI: <http://doi: 10.3748/wjg.v20.i1.6>.
  5. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365(23): 2205–2219. Dostupné z DOI: <http://doi: 10.1056/NEJMra1004965>.
  6. Liu T, Zhang L, Joo D et al. NF-κB signaling in inflammation. Signal Transduct Targeted Ther 2017; 2: e17023. Dostupné z DOI: <http://doi: 10.1038/sigtrans.2017.23 >.
  7. Noort AR, Tak PP, Tas SW. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis Res Ther 2015;17(1):15. Dostupné z DOI: <http://doi: 10.1186/s13075–015–0527–3>.
  8. Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res 2011; 21: 71–85. Dostupné z DOI: <http://doi: 10.1038/cr.2010.177>.
  9. Beinke S, Ley SC. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 2004; 382(Pt 2): 393–409. Dostupné z DOI: <http://doi: 10.1042/BJ20040544>.
  10. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27: 693–733. Dostupné z DOI: <http://doi: 10.1146/annurev.immunol.021908.132641>.
  11. Zhang H, Sun SC. NF-kappaB in inflammation and renal diseases. Cell Biosci 2015; 5: 63. Dostupné z DOI: <http://doi: 10.1186/s13578–015–0056–4>.
  12. Karin M, Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 2000; 12(1): 85–98. Dostupné z DOI: <http://doi: 10.1006/smim.2000.0210>.
  13. Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol 2008; 29(10): 469–478. . Dostupné z DOI: <http://doi: 10.1016/j.it.2008.07.003>.
  14. Israel A. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2010; 2(3):a000158. Dostupné z DOI: <http://doi: 10.1101/cshperspect.a000158>.
  15. Wei F, Chang Y, Wei W. The role of BAFF in the progression of rheumatoid arthritis. Cytokine 2015; 76(2): 537–544. Dostupné z DOI: <http://doi: 10.1016/j.cyto.2015.07.014>.
  16. Tas SW, Remans PH, Reedquist KA et al. Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy. Curr Pharm Des 2005; 11(5): 581–611.
  17. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001;107(1): 7–11. Dostupné z DOI: <http://doi: 10.1172/JCI11830>.
  18. Weih F, Carrasco D, Durham SK et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 1995; 80(2): 331–340.
  19. Aya K, Alhawagri M, Hagen-Stapleton A et al. NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest 2005; 115(7): 1848–1854. Dostupné z DOI: <http://doi: 10.1172/JCI23763>.
  20. Bresnihan B, Pontifex E, Thurlings RM et al. Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers. J Rheumatol 2009; 36(8): 1800–1802. Dostupné z DOI: <http://doi: 10.3899/jrheum.090348>.
  21. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003; 423(6937): 356–361. Dostupné z DOI: <http://doi: 10.1038/nature01661>.
  22. Rochette L, Meloux A, Rigal E et al. The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases. Pharmacol Ther 2018; 82: 115–132. Dostupné z DOI: <http://doi: 10.1016/j.pharmthera.2017.08.015>.
  23. Kiechl S, Werner P, Knoflach M et al. The osteoprotegerin/RANK/RANKL system: A bone key to vascular disease. Expert Rev Cardiovasc Ther 2006; 4(6): 801–811. Dostupné z DOI: <http://doi: 10.1586/14779072.4.6.801>.
  24. Jono S, Otsuki S, Higashikuni Y et al. Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease. J Thromb Haemost 2010; 8(6): 1170–1175. Dostupné z DOI: <http://doi: 10.1111/j.1538–7836.2010.03833.x>.
Štítky
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology Osteology
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Clinical Osteology

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