The Mechanisms of Neurodegeneration in Parkinson’s Disease
Authors:
D. Petrleničová; K. Gmitterová; J. Benetin
Authors place of work:
II. neurologická klinika LF UK a FNsP Bratislava
Published in the journal:
Cesk Slov Neurol N 2010; 73/106(6): 645-649
Category:
Review Article
Summary
Parkinson’s disease is the most common neurodegenerative disorder, with serious socio-economic consequences. At present the disorder appears incurable, but well-timed diagnostics and appropriate therapy can improve the quality of life for those who suffer from it. Recent research appears to support a hypothesis that oxidative damage and mitochondrial dysfunction may play a primary role in the pathogenesis of PD. Further investigation of the mechanisms implicated in the complex process of neurodegeneration may result in the possibility of identifying individuals at risk and presymptomatic patients, and also determining proper therapeutic targets and subsequent neuroprotective treatments.
Key words:
Parkinson’s disease – neurodegeneration – oxidative damage – mitochondrial dysfunction – neuroprotective treatment
Zdroje
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Štítky
Paediatric neurology Neurosurgery NeurologyČlánok vyšiel v časopise
Czech and Slovak Neurology and Neurosurgery
2010 Číslo 6
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