Comparison of Intraocular Pressure Lowering Efficacy of Bimatoprost / Timolol Fixed Combination and Other Glaucoma Medications in the Treatment of Glaucoma
Authors:
K. Skorkovská
Authors place of work:
Klinika nemocí očních a optometrie LF MU Fakultní nemocnice u sv. Anny, Brno, přednosta doc. MUDr. Svatopluk Synek, CSc.
Published in the journal:
Čes. a slov. Oftal., 64, 2008, No. 4, p. 144-148
Summary
Aim:
To compare intraocular pressure (IOP) lowering efficacy of bimatoprost 0.03 % / timolol 0.5 % fixed combination (BTFC) and other combinations of glaucoma drugs (bimatoprost, latanoprost 0.005 % / timolol 0.5 % fixed combination, separate use of travoprost 0.004 % and timolol 0.5 %) in patients with glaucoma.
Patients and methods:
Fifty-three patients with glaucoma were divided into 3 groups according to their original glaucoma therapy. BTFC was used by the patients for a period of 3 months. After 1 week, 1, 2 and 3 months, the diurnal IOP curves were performed. Side effects of the new treatment were recorded and compared to the original therapy.
Results:
The mean diurnal IOP reduction in the group of patients switching from bimatoprost to BTFK reached 4.4 ±2.28 mm Hg (p<0.01). In the group of patients initially on latanoprost / timolol fixed combination, the IOP decreased with BTFK by 2.3 ± 1.5 mm Hg (p<0.01). Changing therapy from travoprost / timolol seperate combination to BTFK caused an IOP decrease by 2.3 ± 1.5 mm Hg on average (p<0.01). Conjunctival hyperemia with initial therapy was experienced in 33 % of patients in our study group. With BTFK application, the hyperemia improved in 69 % of these patients, got worse in 12.5 % and remained unchanged in 19 % of the patients. Patients found the BTFK better than the original medication in 37.5 % of cases, the same in 52 % and worse in 10.5 %. Five patients terminated the study earlier due to poor IOP compensation or marked side effects of BTFK.
Conclusion:
In all three groups of glaucoma patients there was a significant and prolonged decrease in IOP after treatment with BTFK. The use of BTFK was accompanied by smaller incidence of conjunctival hyperemia compared to isolated bimatoprost or travoprost / timolol combination.
Key words:
bimatoprost, timolol, fixed combination, glaucoma
Zdroje
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Štítky
OphthalmologyČlánok vyšiel v časopise
Czech and Slovak Ophthalmology
2008 Číslo 4
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