Sodium Pegaptanib and Ranibizumab in the Treatment of the Retinal Pigment Layer Ablation in a Patient with Age-Related Macular Degeneration – A Case Report
Authors:
M. Šín; J. Šimičák; Z. Prachařová; J. Řehák
Authors place of work:
Oční klinika FN a UP, Olomouc, přednosta doc. MUDr. Jiří Řehák, CSc.
Published in the journal:
Čes. a slov. Oftal., 66, 2010, No. 3, p. 138-141
Category:
Case Report
Summary
The case report presents the difference of the effect of two drugs blocking vascular endothelial growing factor (anti-VEGF) – sodium pegaptanib and ranibizumab – in a female patient with the retinal pigment epithelium (RPE) layer ablation as a part of the exsudative age-related macular degeneration.
Fifty-five years old female patient with RPE ablation as a sign of exsudative ARMD and central visual acuity 79 letters of the EDTRS chart in the left eye was treated by 5 intravitreal injections of sodium pegaptanib. The treatment was not sufficiently effective according to the fluorescein angiography (FAG) and optic coherence tomography (OCT) findings and was accompanied by further decrease of the visual acuity to 55 letters of the EDTRS chart. After the medication was switched to ranibizumab with 3 intravitreal applications, the RPE ablation flattened according to the OCT findings and the fluorescein leakage during the FAG markedly decreased. The central visual acuity improved to 63 letters of the EDTRS chart. The decreased activity of the choroidal neovascularization (CNV) is observed during the following 4 months after the last intravitreal application of ranibizumab.
Ranibizumab seems to be more effective drug comparing to the sodium pegaptanib in patients with the RPE ablation, but it is necessary to consider the increased probability of the RPE rupture risk.
Key words:
age-related macular degeneration, retinal pigment epithelium ablation, ranibizumab, sodium pegaptanib
Zdroje
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Štítky
OphthalmologyČlánok vyšiel v časopise
Czech and Slovak Ophthalmology
2010 Číslo 3
Najčítanejšie v tomto čísle
- Treatment of the Choroidal Neovascular Membrane by Ranibizumab (Lucentis): A Case Report
- Epidemiology of the Age-Related Macular Degeneration
- The Change of the anti-VEGF Agent in the Treatment of Exceptionally Active Choroidal Neovascular Membrane in Age-Related Macular Degeneration
- Combined Therapy in the Exsudative Age-Related Macular Degeneration (Photodynamic Therapy and Intravitreally-Applied Ranibizumab)