Efficacy and Tolerability of Preservative-free Tafluprost 0.0015 % in the Treatment of Glaucoma and Ocular Hypertension
Authors:
M. Karhanová; P. Mlčák; Z. Fryšák; K. Marešová
Authors place of work:
Oční klinika LF UP a FN, Olomouc, přednosta Doc. MUDr. Jiří Řehák, CSc., FEBO
Published in the journal:
Čes. a slov. Oftal., 68, 2012, No. 4, p. 150-155
Category:
Original Article
Summary
Aim:
The aim of the study was to evaluate the efficacy, safety and local tolerability of preservative-free tafluprost 0.0015% (Taflotan®) in patients with glaucoma and ocular hypertension.
Materials and methods:
Multicentric, prospective observation study was performed in the Czech Republic from October 2010 to April 2011. A total of 78 centers participated and 754 patients were included. After the doctor’s decision to start the treatment with Taflotan®, the patient’s demographic data, previous treatment, intraocular pressure and the reason for switching the medication were recorded. At the follow-up visit after 6–12 weeks, the intraocular pressure, local tolerability (a 5-level scale), the patient’s and doctor’s satisfaction (a 4-level scale), and the patient’s preference were recorded.
Results:
Altogether, data of 496 patients were evaluated. The majority of them were women (64.9 %). The patients’ mean age was 58.5 years. The most common diagnosis was primary open angle glaucoma (79.2 %), followed by ocular hypertension (7.3 %), normal tension glaucoma (4.2 %), and pseudoexfoliation glaucoma (3.6 %). In 140 patients, tafluprost 0.0015% was the first antiglaucomatous medication started, 261 patients switched from another monotherapy, and 95 patients were treated with fixed- or nonfixed combinations before starting tafluprost 0.0015%. The most common reason for switching to Taflotan® was local intolerability to the current antiglaucomatous therapy (most often irritation of the eye and hyperemia). The intraocular pressure decreased significantly from 19.9 ± 4.5 mm Hg to 16.3 ± 3.0 mm Hg (p < 0.001). The subjective tolerability of the antiglaucomatous therapy improved rapidly, with 57.4 % of patients rating the tolerability of Taflotan® as “very good” and 34.5 % as “good”. In addition, 94.4 % of patients and 96.0 % of ophthalmologists were “very satisfied” or “satisfied” with the treatment. At the final visit, 79.8 % of patients preferred Taflotan® to the previous treatment.
Conclusion:
Taflotan® significantly decreased the intraocular pressure. It was well tolerated even in patients with previous intolerability to another antiglaucomatous therapy, including prostaglandins. The patients’ and ophthalmologists’ satisfaction with Taflotan® was high.
Key words:
tafluprost, intraocular pressure, prostaglandin analogs, local tolerability, hyperemia, preservatives
Zdroje
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Štítky
OphthalmologyČlánok vyšiel v časopise
Czech and Slovak Ophthalmology
2012 Číslo 4
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