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Retinal Tubulation


Authors: V. Matušková
Authors place of work: Oční klinika FN a LF MU, Brno přednostka prof. MUDr. Eva Vlková, CSc.
Published in the journal: Čes. a slov. Oftal., 71, 2015, No. 2, p. 83-86
Category: Comprehensive Report

Summary

The aim of this study is to present a new retinal structure which is detectable on OCT scans - outer retinal tubulations (ORT). The discovery of these structures is related to more and more perfect retinal imaging using the spectral domain optical coherence tomography (SD OCT).

Outer retinal tubulations were first described by Zweifel et al. in the year 2009 in patients with age-related macular degeneration. These branching tubular structures are localized in the outer nuclear layer of the retina. They are of circular or ovoid shape, with hyporeflectivity in the center, their borders are hyperreflective.

Retinal tubulations are mostly seen together with choroid neovasculare membrane or with retinal pigment epithelium atrophy. Typically, they are adjacent to the area of wide damage of the outer retinal structure combined with relatively good preserved photoreceptor layer (respectively junctions between inner and outer photoreceptors segments), often they overlap the area of subretinal fibrosis or RPE (retinal pigment epithelium) damage. In eyes with anti-VEGF (vascular endothelial growth factor) treatment, they do appear in the area, where, before the treatment, the intraretinal fluid was present.

These structures may simulate CME or the presence of subretinal fluid, so their determination plays an important role in the indications of next anti-VEGF drugs’ applications. Their non-detection may cause unneeded re-applications of anti-VEGF drugs into the viterous.

This study was presented as a lecture at the Congress of the Czech VitreoRetinal Society in Dolní Morava (Czech Republic, E.U.) in the year 2014.

Key words:
outer retinal tubulations (ORT), cystoid macular edema (CME), age-related macular degeneration (ARMD), optical coherence tomography (OCT)


Zdroje

1. Curcio, CA., Medeiros, NE., Millican, CL.: Photoreceptor loss in age-related macular degeneration. Invest Ophthalmol Vis Sci, 37; 1996: 1236–1249.

2. Dirani, A., Gianniou,C., Marchionno, L. et al.: Incidence of outer retinal tubulation in ranibizumab-treated age-related macular degeneration. Retina, 2015, Epub ahead of print, PMID: 25574786.

3. Dolz-Marco, R., Gallego-Pinazo, R. Pinazo-Duran, MD. et al.: Outer retinal tubulation analysis in cases of macular dystrophy. Archivos de la Sociedad Espanola de Oftalmologia, 88; 2013 161–2.

4. Faria-Correia,F., Barros-Pereira, R, Queirós-Mendanha, L.: Characterization of neovascular age-related macular degeneration patients with outer retinal tubulations. Ophthalmologica, 229; 2013: 147–51.

5. Fischer, MD., Huber, G., Beck, SC., et al.: Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One 4;2009: 7507.

6. Gallego-Pinazo, R., Marsiglia, M., Mrejen, S., Yannuzzi, LA.: Outer retinal tubulations in chronic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol, 251; 2013: 1655–6.

7. Goldberg, N., Greenberg, JP., Laud, K. et al.: Outer retinal tubulation in degenerative retinal disorders. Retina, 33; 2013: 1871–1876.

8. Hariri, A., Nittala, MG, Sadda SR.: Outer Retinal Tubulation as a Predictor of the Enlargement Amount of Geographic Atrophy in Age-Related Macular Degeneration. Ophthalmology, 2014 Oct 11. pii: S0161-6420(14)00804-5.

9. Iriyama, A., Aihara, Y., Yanagi, Y: Outer retinal tubulation in inherited retinal degenerative disease. Retina, 33; 2013: 1462–5.

10. Jung, JJ., Freund, KB.: Long-term follow-up of outer retinal tubulation documented by eye-tracked and en face spectral-domain optical coherence tomography.A rch Ophthalmol, 130; 2012: 1618–9.

11. Lee, JY., Folgar, FA., Maguire, MG. et al.: Outer Retinal Tubulation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Ophthalmology, 121; 2014: 2423–31.

12. Maftouhi, MQE., Wolff, B., Mauget-Faÿsse, M.: Outer retinal cysts in exudative age-related macular degeneration: a spectral domain OCT study. Journal Francais d’Ophtalmologie, 33; 2010: 605–609.

13. Mateo-montoya, A., Wolff, B., Sahel, JA. et al.: Outer retinal tubulations in serpinginous choroiditis. Graefe’s Archive for Clinical and Experimental Ophthalmology, 251; 2013: 2657-8.

14. Papastefanou, VP., Nogueira, V., Hay, G. et al.: Choroidal naevi complicated by choroidal neovascular membrane and outer retinal tubulation. British J Ophthalmol, 97; 2013: 1014–9.

15. Tulvatana, W., Adamian, M., Berson, EL. et al.: Photoreceptor rosettes in autosomal dominant retinitis pigmentosa with reduced penetrance. Arch Ophthalmol, 117; 1999: 399–02.

16. Wolff, B., Maftouhi, MQE., Mateo-Montoya, A. et al.: Outer retinal cysts in age-related macular degeneration. Acta Ophthalmol, 89; 2011: 496–499.

17. Wolff, B., Matet, A., Vasseur, V. et al.: En face OCT imaging for the diagnosis of outer retinal tubulations in age-related Macular degeneration. J Ophthalmol, 2012; 2012: 542417.

18. Zweifel, SA., Engelbert, M., Laud, K. et al. : Outer retinal tubulation: a novel optical coherence tomography finding. Arch Ophthalmol., 127; 2009: 1596–602.

Štítky
Ophthalmology
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