„Ganglion Cells Complex“ and Retinal Nerve Fiber Layer in Hypertensive and Normal-Tension Glauc
Authors:
J. Lešták 1,2; Š. Pitrová 1
Authors place of work:
Oční klinika JL s. r. o., V Hůrkách 1 96/10, 158 00 Praha 5 – Nové Butovice
vedoucí lékař doc. MUDr. Ján Lešták, CSc., MSc, MBA, LLA, DBA, FEBO, FAOG
1; Fakulta biomedicínského inženýrství, České vysoké učení technické v Praze
Katedra zdravotnických oborů a ochrany obyvatelstva, Kladno
vedoucí katedry prof. MUDr. Leoš Navrátil, CSc.
2
Published in the journal:
Čes. a slov. Oftal., 72, 2016, No. 6, p. 199-203
Category:
Original Article
Summary
Aim:
To determine, if in the group of hypertensive (HTG) and normal-tension glaucomas exists correlation among ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) in the same altitudinal half of the retina and sum of sensitivities of the visual field’s opposite half (hemifield test) of the same eye.
Materials and methods:
In the HTG group, there were 25 patients; thereof 12 women of the average age 53.23 years (range, 34 – 69 years) and 13 men of the average age 60.38 years (37 – 74 years). In the second group with NTG were 17 women of the average age 55.35 years (25 – 75 years) and 8 men of the average age 55.5 years (32 – 69 years). The including criteria in the study were: visual acuity 1.0 with possible correction smaller than ± 3 dioptres, approximately the same extent of changes in visual fields in all patients (with beginning stage of the disease), no other ophthalmologic or neurological disease. In patients with NTG, the diagnosis was confirmed by means of electrophysiological examination. The thicknesses of the GCC, as well as the RNFL were measured by means of SD-OCT RTvue – 100. The visual fields were examined by fast threshold glaucoma program with the Medmont M 700 perimeter. Th e summation of sensitivities in apostilbes (asb) was counted in the extent 0 – 22 degree in the upper as well as in the lower half of the visual field. Afterwards, the results of the sensitivities summations were compared to the opposite altitudinal half of the retina of the same eye (GCC and RNFL). To compare the dependence among selected parameters, the Pearson’s correlative coefficient r was used.
Results:
To compare the dependence among selected parameters, the Pearson’s correlative coefficient was used. Comparing GCC and the sensitivity in the hemifield test we determined medium-strength correlation in NGT-patients only. Similar correlation we noticed also between RNFL and visual field, except of RNFL in the upper half of the retina and lower hemifield test (r=0.3, p=0.1). In HTG, we did not determine any statistically significant correlation.
Conclusion:
Comparing GCC, RNFL, and visual fields, we determined medium-strength correlation in NTG only, which shows the evidence of difference of both diagnostic groups.
Key words:
GCC, RNFL, visual field, hypertensive glaucoma (HTG), normal-tension glaucoma (NTG)
Zdroje
Araie M, Yamagami J, Suziki Y: Visual field defects in normal-tension and high-tension glaucoma. Ophthalmology, 100; 1993: 1808–1814.
2. Bowd C, Tafreshi A, Zangwill LM, Medeiros FA, Sample PA, Weinreb RN: Pattern electroretinogram association with spectral domain OCT structural measurements in glaucoma. Eye (Lond), 25; 2011: 224–232.
3. Distante P, Lombardo S, Verticchio Vercellin AC, Raimondi M, Rolando M, Tinelli C, Milano G: Structure/Function relationship and retinal ganglion cells counts to discriminate glaucomatous damages. BMC Ophthalmol, 29; 2015: 185. doi: 10.1186/s128860150177x.
4. Eid TE, Spaeth GL, Moster MR, Augburger JJ: Quantitative differences between the optic nerve head and peripapillary retina in low-tension glaucoma and high-tension primary open-angle glaucoma. Am J Ophthalmol, 124; 1997: 805–813.
5. Flammer J, Prünte C: Ocular vasospasm. 1: Functional circulatory disorders in the visual system, a working hypothesis. Klin Monbl Augenheilkd, 198; 1991: 411–412.
6. Chang M, Yoo C, Kim SW, Kim YY: Retinal Vessel Diameter, Retinal Nerve Fiber Layer Thickness, and Intraocular Pressure in Korean Patients with Normal-Tension Glaucoma. Am J Ophthalmol, 151; 2011: 100–105.
7. Cheng HC, Chan CM, Yeh SI, Yu JH, Liu DZ: The Hemorheological Mechanisms in Normal Tension Glaucoma. Curr Eye Res, 36; 2011: 647–653.
8. Jeoung JW, Choi YJ, Park KH, Kim DM: Macular ganglion cell imaging study: glaucoma diagnostic accuracy of spectraldomain optical coherence tomography. Invest Ophthalmol Vis Sci, 54; 2013: 4422–4429.
9. Kim NR, Hong S, Kim JH, Rho SS, Seong GJ, Kim CY: Comparison of macular ganglion cell complex thickness by Fourier-domain OCT in normal tension glaucoma and primary open-angle glaucoma. J Glaucoma, 22; 2013: 133–139.
10. Lešták J, Nutterová E, Pitrová Š, Krejčová H, Bartošová L, Forgáčová V: High tension versus normal tension glaucoma. A comparison of structural and functional examinations. J Clinic Exp Ophthalmol 2012, S:5, http://dx.doi.org/10.4172/2155-9570.S5-006. ISSN: 2155–9570
11. Lestak J, Nutterova E, Bartosova L, Rozsival P: The Visual Field in Normal tension and Hypertension Glaucoma. International Journal of Scientific Research, 3; 2014: 49–51.
12. Lestak J, Nutterova E, Jiraskova N, Navratil L: Ganglion cell complex and nerve fibre layer in hypertension and normal-tension glaucoma. Wulfenia Journal, 23; 2016: 2–12.
13. Lester M, De Feo F, Douglas GR: Visual field loss morphology in high- and normal-tension glaucoma. J Ophthalmol, 2012; 327326. Epub 2012: Feb 8.
14. Na JH, Lee K, Lee JR, Baek S, Yoo SJ, Kook MS: Detection of macular ganglion cell loss in preperimetric glaucoma patients with localized retinal nerve fiber defects by spectraldomain optical coherence tomography. Clin Experiment Ophthalmol, 41; 2013: 870–880.
15. Nouri Mahdavi K, Nowroozizadeh S, Nassiri N, Cirineo N, Knipping S, Giaconi J, Caprioli J: Macular ganglion cell/inner plexiform layer measurements by spectral domain optical coherence tomography for detection of early glaucoma and comparison to retinal nerve fiber layer measurements. Am J Ophthalmol, 156; 2013: 1297–1307.
16. Okuno T, Sugiyama T, Kojima S, Nakajima M, Ikeda T: Diurnal variation inmicrocirculation of ocular fundus and visual field change in normal-tension glaucoma. Eye (Lon), 18; 2004: 697–702.
17. Plange N, Remky A, Arend O: Colour Doppler imaging and fluorecein filling defects of the optic disc in normal tension glaucoma. Br J Ophthalmol, 87; 2003: 731–736.
18. Rao HL, Yadav RK, Addepalli UK, Begum VU, Senthil S, Choudhari NS, Garudadri CS: Comparing spectraldomain optical coherence tomography and standard automated perimetry to diagnose glaucomatous optic neuropathy. J Glaucoma, 24; 2015: 69–74.
19. Schwenn O, Troost R, Vogel A, Grus F, Beck S, Pfeiffer N: Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. Br J Ophthalmol, 86; 2002: 981–984.
20. Shin IH, Kang SY, Hong S, Kim SK, Seong GJ, Ma KT, Kim CY: Comparison of OCT and HRT findings among normal tension glaucoma, and high tension glaucoma. Korean J Ophthalmol, 22; 2008: 236–241.
21. Takeyama A, Kita Y, Kita R, Tomita G: Influence of axial length on ganglion cell complex (GCC) thickness and on GCC thickness to retinal thickness ratios in young adults. Jpn J Ophthalmol, 58; 2014: 86–93.
Štítky
OphthalmologyČlánok vyšiel v časopise
Czech and Slovak Ophthalmology
2016 Číslo 6
Najčítanejšie v tomto čísle
- Central Serous Chorioretinopathy as a Masquerading Syndrome of Choroidal Hemangioma
- Difficult Diagnosis of Non-strabismic Binocular and Accommodative Disorders
- AMNIOTIC MEMBRANE APPLICATIONS – OUR EXPERIENCE
- Disorders of Simple Binocular Vision in Heterophoria and their Spectacle Correction