Color Vision Deficiency in Alcoholics and its Relationship with the BDNF Polymorphism
Authors:
O. Šerý; J. Lochman; P. Zvolský 1; Z. Hlinomazová 2; M. Novotný 1
Authors place of work:
Laboratoř neurobiologie a molekulární psychiatrie, Laboratoře molekulární fyziologie, Ústav biochemie
Přírodovědecká fakulta MU, Brno
ředitel Ústavu biochemie doc. Ing. M. Mandl, CSc.
Psychiatrická klinika 1. LF UK a VFN, Praha
; přednosta prof. MUDr. J. Raboch, DrSc.
Oční klinika FN Brno
1; přednostka prof. MUDr. E. Vlková, CSc.
2
Published in the journal:
Čes. a slov. Psychiat., 104, 2008, No. 3, pp. 115-119.
Category:
Original Article
Summary
Alcoholism induces the brain damage but it may also cause the color vision deficiency. In our association study of genetic dispositions to the alcoholism in 167 alcoholics and 289 non-alcoholic controls, we studied a relationship between candidate genes and alcoholism. In all subjects involved in this study many factors, e.g. color vision deficiencies, were examined. Surprisingly, after the statistical analysis, we found that 47.9% of alcoholics have problems with color vision deficiency and moreover that this color vision deficiency is in a relationship with the polymorphism of BDNF (Brain-derived neurotrophic factor) gene. It is well known that BDNF plays a role in the neurodevelopment of retina and in the protection of photoreceptors from apoptosis. Potential role of BDNF gene in the color vision deficiency in alcoholics is discussed.
Key words:
alcoholism, BDNF, retina, vision, color, apoptosis, GABA.
Zdroje
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Štítky
Addictology Paediatric psychiatry PsychiatryČlánok vyšiel v časopise
Czech and Slovak Psychiatry
2008 Číslo 3
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Najčítanejšie v tomto čísle
- The Val158Met Polymorphism of the Catechol-O-Methyltransferase Gene and Psychotic Symptoms in Methamphetamine Dependence
- A Historical Review of Development of the Concept of Congruence
- Color Vision Deficiency in Alcoholics and its Relationship with the BDNF Polymorphism