Birth Defects, Medical Outcome and Somatic Development in Children Conceived after Intracytoplasmic Sperm Injection (ICSI)

Česká verzia

Authors: M. Šnajderová ^1,2; D. Zemková ¹; T. Mardešić ^2,3; A. Šípek ^4,5; V. Gregor ^2,6; D. Krejčířová ^2,7; D. Sobotková ⁴; J. Kraus ⁸; V. Lánská ⁹
Authors place of work: Pediatrická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Lebl, CSc. ¹; Institut postgraduálního vzdělávání ve zdravotnictví, Praha, ředitel MUDr. A. Malina, Ph. D. ²; Sanatorium Pronatal, Praha, vedoucí lékař doc. MUDr. T. Mardešić, CSc. ³; Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc. ⁴; 3. LF UK, Praha, děkan doc. MUDr. B. Svoboda, CSc. ⁵; Oddělení klinické genetiky, Fakultní Thomayerova nemocnice, Praha, ředitel MUDr. K. Filip, CSc., MBA ⁶; Oddělení klinické psychologie, Fakultní Thymayerova nemocnice, Praha, ředitel MUDr. K. Filip, CSc., MBA ⁷; Dětská neurologická klinika, 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. V. Komárek, CSc. ⁸; Oddělení statistiky, IKEM, Praha, ředitel doc. MUDr. J. Malý, CSc. ⁹
Published in the journal: Ceska Gynekol 2008; 73(1): 22-29

Summary

Objective:
To analyze the incidence of birth defects, medical outcome and somatic development in children conceived after intracytoplasmic sperm injection (ICSI).

Design:
Prospective open cross-sectional clinical study.

Setting:
University hospital and private IVF unit.

Methods:
135 Czech children (59 girls, 76 boys) from singleton and twin pregnancies conceived after ICSI (age 0.3-9.5 years; median 5.9) were assessed during the period 2004-2006. The incidence of birth defects, medical outcome and somatic development were evaluated and compared with data of general population and/or with control group matched for sex and age.

Results:
Birth defects were found in 13.3% of ICSI children (compared to 4.6% in children after spontaneous conception; p<0.001). The general health of ICSI children did not differ significantly compared to general population. ICSI children required more surgery or hospitalization compared to general population data. There is high rate (69.6%) among ICSI children in the care of various specialised clinics. Body height and weight in ICSI children is in normal range and corresponds to their growth potential. Head circumference in ICSI children is larger compared to reference data (0.43 SD; p<0.001).

Conclusions:
No clinically important differences in somatic development between ICSI and general population of Czech children were found. Birth defects were more frequent in ICSI children. The overall general health in ICSI children seems satisfactory but ICSI children were more likely to need health care compared to general population.

Key words:
ICSI, children, congenital structural malformations, medical outcome, somatic development.

Zdroje

1. Agarwal, P., Loh, SK., Lim, SB., et al. Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study. BJOG, 2005, 112, p. 1376–1383.

2. Andersen, AN., Gianaroli, L., Felberbaum, R., et al. The European IVF-monitoring programme (EIM), European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod, 2005, 20, 5, p. 1158-1176.

3. Belva, F., Henriet, S., Liebaers, I., et al. Medical outcome of 8-year-old singleton ICSI children (born >or=32 weeks‘ gestation) and a spontaneously conceived comparison group. Hum Reprod, 2007, 22, 2, p. 506-515.

4. Bláha, P., Vignerová, J., Riedlová, J., et al. Celostátní antropologický výzkum dětí a mládeže 2001, Česká republika. SZÚ Praha, 2005.

5. Bonduelle, M., Liebaers, I., Deketelaere, V., et al. Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999). Hum Reprod, 2002, 17, 3, p. 671-94.

6. Bonduelle, M., Bergh, C., Niklasson A., et al. Medical follow-up study of 5-year-old ICSI children. Reprod Biomed Online, 2004, 9, 1, p. 91-101.

7. Bonduelle, M., Wennerholm, UB., Loft, A., et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod, 2005, 20, 2, p. 413-419.

8. Bowen, JR, Gibson, FL, Leslie, GI, Saunders, DM. Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection. Lancet, 1998, 351, p. 1529-1534.

9. Brandes, JM., Scher, A., Itzkovits, J., et al. Growth and development of children conceived by in vitro fertilization. Pediatrics, 1992, 90, p. 424–429.

10. De Kretser, DM. The potential of intracytoplasmic sperm injection (ICSI) to transmit genetic defects causing male infertility. Reprod Fertil Dev, 1995, 7, 2, p. 137-141; discussion 141-142.

11. Ericson, A., Nygren, KG, Olausson, O., Källén, B. Hospital care utilization of infants after IVF. Hum Reprod, 2002, 17, p. 929-932.

12. Hansen, M., Kurinczuk, JJ., Bower, C., et al. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med, 2002, 346, p. 725-730.

13. Hansen, M., Bower, C., Milne, E., et al. Assisted reproductive technologies and the risk of birth defects – a systematic review. Hum Reprod, 2005, 20, p. 328–338.

14. Katalinic, A., Rösch, C., Ludwig, M., and German ICSI Follow-Up Study Group. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril, 2004, 81, 6, p. 1604-1616.

15. Koivurova, S., Hartikainen, AL., Sovio, U., et al. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod, 2003, 18, p. 2328–2336.

16. Koivurova, S., Hartikainen, AL., Gissler, M., et al. Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study. Hum Reprod, 2007, 22, 8, p. 2136-2141.

17. Kurinczuk, J. Safety issues in assisted reproduction technology. Hum Reprod, 2003, 18, 5, p. 925-931.

18. Ludwig, M. Development of children born after IVF and ICSI.Reproductive BioMedicineOnline, on web 11 May 2004 www.rbmonline.com/Article/1365.

19. Mau, C., Juul, A., Main, KM, Loft, A. Children conceived after intracytoplasmic sperm injection (ICSI): is there a role for paediatrician? Acta Paediatr, 2004, 93, p. 1238-1244.

20. Mau Kai, C., Main, KM., Andersen, AN., et al. Serum insulin-like growth factor i (igfi) and growth in children born after assisted reproduction. J Endocrinol Metab, 2006, 91, 11, p. 4352-4360.

21. MKN-10. Mezinárodní statistická klasifikace nemocí a přidružených zdravotních problémů. Desátá revize-abecední seznam. WHO-ÚZIS, ČR.

22. Palermo, GD., Joris, H., Devroey, P., Van Steirteghem, AC. Pregnancies after cytoplasmic injection of single spermatozoon into oocyte. Lancet, 1992, 340, p. 17-18.

23. Patrizio, P. Intracytoplasmic sperm injection (ICSI): potential genetic concerns. Hum Reprod, 1995, 10, p. 2520-2523.

24. Pinborg, A., Loft, A., Schmidt, L., Nyboe Andersen, A. Morbidity in Danish cohort of 742 IVF/ICSI twins non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social complications for the children and their families. Hum Reprod, 2003, 18, 6, p. 1234-1243.

25. Pinborg, A., Lidegaard, O., la Cour, FN., Andersen, AN. Consequences of vanishing twins in IVF/ICSI pregnancies. Hum Reprod, 2005, 20, p. 2821–2829.

26. Place, I., Englert, Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil Steril, 2003, 80, p. 1388–1397.

27. Sanchez-Albisua, I., Borell-Kost, S., Mau-Holzmann, UA., et al. Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection. Dev Med Child Neurol, 2007, 49, 2, p. 129-134.

28. Silber, SJ., Repping, S. Transmision of male infertility to future generations: lessons from the Y chromosome. Hum Reprod, 2002, 8, 3, p. 217-229.

29. Saunders, K., Spensley, J., Munro, J., Halasz, G. Growth and physical outcome of children conceived by in vitro fertilization. Pediatrics, 1996, 97, p. 688–692

30. Slováčková, D. Vývoj některých antropometrických charakteristik a svalového tonu u českých dětí. Diplomová práce. Univerzita Karlova v Praze, Přírodovědecká fakulta. Katedra antropologie a genetiky člověka, Praha 2006.

31. Sutcliffe, AG., Taylor, B., Saunders, K., et al. Outcome in the second year of life after in-vitro fertilisation by intrycytoplasmic serm injection: a UK case-control study. Lancet, 2001, 357, p. 2080-2084.

32. Šípek, A., Gregor, V., Horáček, J., et al. Stav dětí narozených po asistované reprodukci v ČR. Čes Gynek, 2004, 69, Suppl., s. 42-46.

33. Šípek, A., Gregor, V., Horáček J. Vrozené vady v české republice v období 1994-2005-perinatologická data. Čes Gynek, 2007, 72, 2, s. 103-109.

34. Šnajderová, M., Mardešić, T., Zemková, D., et al. Děti narozené po intracytoplazmatické injekci spermie (ICSI): faktory neplodnosti, průběh těhotenství a porodu, perinatální období. Čes Gynek, 2008, 1. s. 16–21.

35. Ústav zdravotnických informací a statistiky ČR (ÚZIS). Národní registr hospitalizovaných, Národní registr novorozenců, Národní registr vrozených vad, Roční výkaz o činnosti ZZ - dětský a dorostový ČSÚ.

36. Van Golde, R., Boada, M., Veiga, A., et al. A retrospective follow-up study on intracytoplasmic sperm injection. J Assist Reprod Genet, 1999, 16, p. 227–232.

37. Wennerholm, UB., Bergh, C., Hamburger, L., et al. Incidence of congenital anomalies in children born after ICSI. Hum Reprod, 2000, 15, p. 944-948.