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The Influence of Inflammatory Bowel Disease on the Period of Conceiving


Authors: M. Pintérová Kolesárová;  M. Pintér;  S. Rejchrt;  T. Douda;  I. Tachecí;  M. Kopáčová;  J. Bureš
Authors place of work: II. interní klinika lékařské fakulty UK a FN, Hradec Králové, Subkatedra gastroenterologie, přednosta prof. MUDr. J. Malý, CSc.
Published in the journal: Ceska Gynekol 2008; 73(2): 109-112

Summary

Introduction:
Crohn’s disease (CD) and ulcerative colitis (UC) influence women fertility in many ways.

Objective:
We tried to determine the influence of the inflammatory bowel disease on conceiving. The date of the diagnosis, localisation, form and activity at time of conception were involved.

Design:
Retrospective study.

Methods:
We assessed data from 81 patients with inflammatory bowel disease. 56 patients were diagnosed before conceiving (41 with CD, 15 with UC), 25 patients were diagnosed after pregnancy (14 with CD, 11 with UC). We assessed the period of conceiving (in months) depends on previous abdominal operation, localisation, form and activity of the disease at time of conception. The data were obtained from the questionnaire and hospital cards.

Results:
The previous abdominal operation, the diagnosis, localisation, and the form of the disease did not influence the period necessary to conceive in patient with inflammatory bowel disease. The anoperineal localisation and activity of Crohn’s disease at the time of conception extended the period necessary to conceive.

Conclusion:
Fertility of the patients with Crohn’s disease depends on the activity of the disease at time of conception and anoperineal involvement. Previous abdominal operation does not influence the fertility.

Key words:
Crohn’s disease, ulcerative colitis, fertility, operation, activity of the disease


Zdroje

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4. Johnson, P., Richard, C., Ravid, A., et al. Female infertility after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum, 2004, 47, p. 1119-1126.

5. Mayberry, JF., Weterman, IT. European survey of fertility and pregnancy in women with Crohn’s disease: a case control study by European collaborative group. Gut, 1986, 27, p. 821-825.

6. Olsen, KO., Joelsson, M., Laurberg, S., Oresland, T. Fertility after ileal pouch-anal anastomosis in women with ulcerative colitis. Br J Surg, 1999, 86, p. 493-495.

7. Olsen, KO., Juul, S., Berndtsson, I., et al. Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample. Gastroenterology, 2002, 122, p. 15-19.

8. Sheiner, E., Shoham-Vardi, I., Hershkovitz, R., et al. Infertility treatment is an independent risk factor for cesarean section among nulliparous women aged 40 and above. Am J Obstet Gynecol, 2001, 185, p. 888-892.

9. Weber-Ziegler, C., Belinson, JL., et al. Gynecologic history of women with inflammatory bowel disease. Obstet Gynec, 1995, 86, p. 843-847.

10. Willoughby, CP., Truelove, SC. Ulcerative colitis and pregnancy. Gut, 1980, 21, p. 469-474.

Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Článok vyšiel v časopise

Czech Gynaecology

Číslo 2

2008 Číslo 2
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