Preterm Premature Rupture of Membranes and Ureaplasma urealyticum
Authors:
M. Kacerovský; L. Boudyš
Authors place of work:
Porodnická a gynekologická klinika LF v Hradci Králové, UK Praha a FN Hradec Králové, přednosta doc. MUDr. J. Tošner, CSc.
Published in the journal:
Ceska Gynekol 2008; 73(3): 154-159
Summary
Objective:
The purpose of this study was to evaluate the prevalence of the maternal lower genital tract colonization by Ureaplasma urealiticum and Mycoplasma hominis in patiens with preterm premature rupture of the membranes.
Design:
Retrospective study.
Setting:
Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Králové.
Methods:
We studied 150 women between 24 and 34 weeks of gestation with preterm premature rupture of the membranes. These patients were divided into 2 groups. In group 1 swabs were obtained for genital mycoplasmas. In both groups 1 and 2 were obtained standard swabs for aerobic and anaerobic cultivation. Control group 3 were women with normal pregnancy.
Results:
Ureaplasma urealyticum was detected in 96% (72/75) of the patients with PPROM between 24 and 34 weeks of gestation and in 32% (24/75) of the patiens of the control group (normal pregnancy).
Conclusion:
The maternal lower genital tract colonization by Ureaplasma urealyticum might be associated with preterm premature rupture of the membranes and chorioamniitis.
Key words:
Ureaplasma urealyticum, chorioamniitis, preterm premature rupture of the membranes.
Zdroje
1. Abele-Horn, M., Scholz, M., Wolff, C., Kolben, M. High density vaginal Ureaplasma urealyticum colonization as a risk factor for chorioamniitis and preterm delivery. Acta Obstet Gynecol Scand, 2000, 79, p. 73-978.
2. Carey, JC., Blackwelder, WC., Nugent, RP. Antepartum cultures for Ureaplasma urealyticum are not usefull in predicting pregnancy outcome. Am J Obstet Gynecol, 1991, 164, p. 728-733.
3. Goldenberg, RL., Anders, WW., Goepfert, AR. The Alabama Preterm Birth Study: Umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. Am J Obstet Gynecol, 2008, 198, p. 43e1-43e5.
4. Eschenbach, DA., Nugent, RP., Rao, AV. A randomized placebo controlled trial of erytromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. Am J Obstet Gynecol, 1991, 164, p. 734-740.
5. Fortunato, SJ., Menon, J., Swan, K., et al. Interleukin 10 inhibition of interleukin 6 in human amniochorion membran: transcriptional regulativ. Am J Obstet Gynecol, 1996, 175, p. 1057-1065.
6. Hadar, A., Ytzhaki, OR., Shani-Shrem, N. Amniotic fluid intercellular adhesion molekule 1 is a marker for Ureaplasma infection in women with preterm labor. Am J Obstet. Gynecol, 2006, 195, p. 1601-1606.
7. Horowitz, S., Horowitz, M., Mazor, M., et al. Ureaplasma urealyticum cervical colonization as a marker for pregnancy complications. Int J Gynecol Obstet, 1995, 48, p. 15-19.
8. Kim, M., Kim, G., Romero, R., et al. Biovar density of Ureaplasma Urealyticum in amniotic fluid. Distribution, intrauterinne inflamatory response and pregnancy outcomes. J Perinat Med, 2003, 31, p. 146-152.
9. Klein, LL., Gibbs, R. Use of microbial cultures and antibiotik in the prevention of infection –associated preterm birth. Am J Obstet Gynecol, 2004, 190, p. 1493-1502.
10. Li, YH., Brauner, A., Jonsson, B. Ureaplasma Urealyticum induced production of proinflamatory cytokines by macrophages. Pediatr Res, 2000, 48, p. 919-924.
11. Maher, CF., Haran, MV., Farrell, DJ. Ureaplasma Urealyticum chorioamniitis. Aust NZ J Obstet Gynecol, 1999, 34, p. 477-479.
12. McDonald, HM., O@Loughlin, JA., Jolley, P. Prenatal microbiological risk factor associated with preterm birth. Br J Obstet Gynecol, 1992, 99, p. 190-195.
13. Menon, R., Camargo, C., Thorsen, P., et al. Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans. Am J Obstet Gynecol, 2008, 198, p. 77e1-77e7.
14. Mitsunari, M., Yoshida, S., Horie, S., et al. Cervical Ureaplasma urealyticum colonization might be associated with increased incidence of preterm delivery in pregnant women without prophlogistic microorganisms on routine examination. J Obstet Gynecol Res, 2001, 31, p. 16-22.
15. Moss, TJM., Knox, CL., Kallapus, SG., et al. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Obstet Gynecol, 2008, 198, p. 122e1-122e8.
16. Ogasawa, KK., Goodwin, TM. The efficacy of prophylactic erytromycin in preventing vertical transmission of Ureaplasma urealyticum. Am J Perinatol, 197, 14, p. 770-775.
17. Paul, VK., Gupta, U., Singh, S., et al. Association of genital mycoplasma colonization with low birth weight. Int J Gynecol Obstet, 1998, 63, p. 109-114.
18. Peltier, M., Barney, MB., Brown, MB. Effect of experimental genital mycoplasmosis on production of matrix metalloproteinases in membranes and amniotic fluid of Sprague-Dawley rats. Am J Reprod Immunol, 2007, 57, p. 116-121.
19. Shim, SS., Romero, R., Hong, JS., et al. Clinical signifikance of intraamniotic inflamation in patiens with preterm prematur rupture of membranes. Am J Obstet Gynecol, 2004, 191, p. 1339-1345.
20. Shobokshi, A., Shaarawy, M. Maternal serum and amniotic fluid cytokines in patiens with preterm premature rupture of membranes with and without intruterinne infection. Int J Gynecol Obstet, 2002, 99, p. 209-215.
21. Vogel, I., Thorsen, P., Curry, A., et al. Biomarkers for prediction of preterm delivery. Acta Obstet Gynecol Scand, 2005, 84, p. 516-525.
22. Yoon, HH., Romero, R., Lim, JH., et al. The clinical signifikance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patiens with preterm labor. Am J Obstet Gynecol, 2000, 183, p. 1130-1137.
23. Watts, DH, Krohn, MA., Hillier, S., et al. The association of amniotic fluid infection with gestation age and neonatal outcome among women in preterm labor. Obstet Gynecol, 1992, 79, p. 351-357.
24. Witt, A., Berger, A., Gruber, J., et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature of the membranes and subsequent cesarean delivery. Am. J. Obstet. Gynecol., 2005,193, p. 1663-1669.
Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineČlánok vyšiel v časopise
Czech Gynaecology
2008 Číslo 3
Najčítanejšie v tomto čísle
- Preterm Premature Rupture of Membranes and Ureaplasma urealyticum
- Postpartal Atraumatic Sacral Fracture. A Case Report and Biomechanical Comments
- Sclerosing Stromal Tumor – a Rare Benign Ovarian Neoplasm
- Etiopathogenesis of Uterine Fibroid: Current Knowledge