Risk-reducing surgery in women at hereditary risk of gynaecological cancer

Česká verzia

Authors: Michal Zikán
Authors place of work: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc.
Published in the journal: Ceska Gynekol 2011; 76(3): 216-221

Summary

Objective:
To present up-to-date knowledge concerning risk-reducing surgery in carriers of susceptibility mutations among hereditary breast/ovarian cancer syndrome and Lynch syndrome.

Subject:
Review.

Setting:
Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague – First Faculty of Medicine and General Faculty Hospital, Prague.

Subject and method:
After having reviewed the now-a-days literature and summarized our experience we present here an overview of risk-reducing strategies in gynecology and a proposal of guidelines to risk-reducing salpingo-oophorectomy and hysterectomy.

Conclusion:
Risk-reducing salpingo-oophorectomy or hysterectomy is the most effective strategy for gynecological cancer prevention in susceptibility gene mutation carriers so far. This type of surgery, however, requires specific indication work-up and techniques different from those standardly used.

Key words:
hereditary breast/ovarian cancer syndrome, hereditary non-polyposis colorectal cancer syndrom, BRCA1, BRCA2, risk-reducing salpino-oophorectomy, risk-reducing hysterectomy.

Zdroje

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