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Position of targeted therapy in ovariancancer management


Authors: M. Majirský 1;  M. Kubecová 1;  E. Kindlová 1;  K. Tikovský 2
Authors place of work: Radioterapeutická a onkologická klinika 3. LF UK a FN KV, Praha, přednostka doc. MUDr. M. Kubecová, Ph. D. 1;  Gynekologicko-porodnická klinika 3. LF UK a FN KV, Praha, přednosta doc. MUDr. E. Kučera, CSc. 2
Published in the journal: Ceska Gynekol 2013; 78(4): 347-350

Summary

Ovarian cancer in Czech Republic takes first place in mortality among gynecological malignant tumours. In most cases it is diagnosed in advanced stages. Initial treatment is based on combination of radical surgery and adjuvant chemotherapy. In more than two thirds of cases ovarian cancer relapses sooner or later, very often without a chance to cure the patient. Unsatisfying result of standard treatment is reason of looking for more effective procedures. Targeted therapy is subject of research in last years. Positive effect of bevacizumab has been proved. Through inhibition of angiogenesis it leads to prolonging of interval to cancer progression.

Keywords:
ovarian cancer – targeted therapy – bevacizumab – QALY


Zdroje

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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Článok vyšiel v časopise

Czech Gynaecology

Číslo 4

2013 Číslo 4
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