Contraceptive vaccinogen – current state of development

Česká verzia

Authors: J. Cibulka
Authors place of work: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Novotný, CSc.
Published in the journal: Ceska Gynekol 2014; 79(1): 12-15

Summary

Objective:
To present an overview of published results of research and practice in the field of searching for the contraceptie vaccinogen.

Design:
Review article.

Settings:
Department of Gynecology and Obstetrics, Medical Faculty in Pilsen, Charles University in Prague and University Hospital in Pilsen.

Objective of study:
The issue of fertility is a growing problem especially in developed countries. The questions of contraception in terms of family planning are intensively discussed. Regardless of the unfavorable development of the number of the population in developed countries, various kinds of contraceptives are still in demand. The widespread availability and reliability confirms a dominant position of hormonal contraception. Due to the known and contemplated negative effects of hormonal contraceptives on the individual as well as on the environment, the immunological aproach offers to become an option with long lasting effect. Therefore it is not surprising that research on contraceptive vaccinogen is most supported in countries such as China or India.

Experiences in research and treatment of otherwise unexplained infertility are also applicable in opposing intentions as immunologically induced down-regulation of fertility.

Conclusion:
Long term research of immunogenicproperties of human sperm indicates, that the possible induction of an immune response to this gametes currently appears to be the safest and also the most difficult way to achieve immunological contraception potentially in both, man and woman.

Keywords:
reproductive immunology – contraceptive vaccinogen – hormonal contraception –sperm antigens – antisperm antibodies

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