HPV in etiology of orofaryngeal cancer according to sexual activity

Česká verzia

Authors: P. Michl ¹; M. Procházka ²; T. Štosová ³; R. Pink ¹; J. Pazdera ¹; P. Tvrdý ¹
Authors place of work: Klinika ústní, čelistní a obličejové chirurgie LF UP a FN, Olomouc, MUDr., Dr. P. Tvrdý, Ph. D. ¹; Ústav mikrobiologie LF UP a FN, Olomouc, prof. MUDr. M. Kolář, Ph. D. ²; Porodnicko-gynekologická klinika LF UP a FN, Olomouc, prof. MUDr. R. Pilka, Ph. D. ³
Published in the journal: Ceska Gynekol 2015; 80(1): 30-36

Summary

Objective:
The objective of this study is to confirm or exclude the presence of the HPV in oral cavity according to sexual activity.

Design:
Prospective not blinded study.

Setting:
Clinic of Oral and Maxillofacial Surgery, Clinic of Obsterics and Gynecology, Department of Microbiology, Medical Faculty Palacky University and University Hospital Olomouc.

Methods:
The patients were examined during the screenig for cervix carcioma at the Clinic of Obsterics and Gynecology. After filling the Consent Form and the questionnaire for possible exposure to potentional risk the swabs from cervix and mouth were sampled. The samples have been processed at the Department of Microbiology by the Real Time PCR.

Results:
The results have not confirmed the relation between sexual practices and infection of oral cavity by the HPV.

Conclusion:
Our results correspond with certain authors. There is unclear correlation between total number of sexual partners and infection of mouth with the HPV. Nevertheless the HPV related tumors have been proven – especially in the oropharynx- but the way how the infection enters the mouth remains still unclear, according to us.

Keywords:
HPV, oral cancer, cervical cancer, non-coital sexual activities, coital sexual activities, PCR

Zdroje

1. Andl, T., Kahn, T., Pfuhl, A., et al. Etiological involvment of oncogenic human papillomavirus in tonsillar squamous cell carcinomsas lacking retinoblastoma cell cycle control. Cancer Res, 1998, 58, p. 5–13.

2. Ang, KK., Harris, J., Wheeler, R., et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med, 2010, 363(1), p. 24–35.

3. Caňadas, MP., Bosch, FX., Junquera, ML., et al. Concordance of prevalence of human papillomavirus DNA in anogenital and oral infections in a high-risk population. J Clin Microbiol, 2004, 42(3), p. 1330–1332.

4. Chaturvedi, AK., Engels, EA., Pfeiffer, RM., et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. JCO, 2011, 29, 32, p. 4294–4301.

5. Chen, R., Aaltonen, LM., Vaheri, A. Human paillomavirus type 16 in head and neck carcinogenesis. Rev Med Virol, 2005, 15, p. 351–363.

6. Dahlgren, L., Dahlstrand, HM., Lindquist, D., et al. Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients, Int J Cancer, 2004, 112(6), p. 1015–1019.

7. Dahlstrand, H. M., Dalianis, T. Presence and influence of human papillomaviruses (HPV) in tonsillar cancer. Adv Cancer Res, 2005, 93, p. 59–89.

8. D‘Souza, G., Kreimer, AR., Viscidi, R., et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med, 2007, 356, p. 1944–1956.

9. Fakhry, C., Westra, WH., Li, S., et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst., 2008, 20,100(4), p. 261–269.

10. Fakhry, C., D´Souza, G., Sugar, E., et al. Relationship between prevalent oral and cervical human papilomavirus infections in human imunodeficiency virus-positive and –negative women.J Clin Microbiol, 2006, 44, p. 4479–4485.

11. Fischer, CA., Zlobec, I., Green, E., et al. Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer, 2010, 126, p. 1256-1262.

12. Gillison, ML., Harris, J., Westra, W., et al. Survival outcomes by tumor human papillomavirus (HPV) status in stage III–IV oropharyngeal cancer (OPC) in RTOG 0129. J Clin Oncol, 2009, 27 (Suppl. 15), Abstract 6003.

13. Gillison, ML., Koch, WM., Capone, RB. Evidence for a causal assotiation between human papillomavirus and subset of head and neck cancers. J Natl Cancer Inst, 2000, 344, p. 1125–1131.

14. Girlando, P., Goncalves, AK., Pereira, SA., et al. Human papillomavirus in the oral mucosa of women with genital human papilomavirus lesion. Eur J Obstet Gynecol Reprod Biol, 2006, 126, p. 104–106.

15. Hannahan, D., Weinberg, RA. The hallmarks of cancer. Cell, 2000, 100(1), p. 57–70.

16. Klozar, J., Zabrodsky, M., Kodet, R., et al. Human papillomaviruses in etiology of carcinoma in oral cavity and oropharynx. Otorinolaryng Foniat, 2007, 56, 2, p. 73–81.

17. Klussmann, JP., Weissenborn, SJ., Wieland, U. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer, 2001, 92, p. 2875–2884.

18. Koch, A., Hansen, SV., Nielsen, NM., et al. HPV detection in children prior to sexual debut. Int J Cancer, 1997, 73, p. 621-624.

19. Laco, J. Lidské papilomaviry a jejich úloha v etiopatogenezi dlaždicobuněčného karcinomu dutiny ústní a orofaryngu. Praha: Galen 2012, s. 81–85.

20. Lassen, P., Eriksen, JG., Hamilton-Dutoit, S., et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol, 2009, 27(12), p. 1992–1998.

21. NCCN Guidelines Version 2.2013. National Comperhensive Cancer Network, Inc. 2013.

22. Novakova, V., Laco, J. Úloha lidského papilomaviru v karcinogenezi nádorů hlavy a krku. Klin Onkol, 2008, 21, s. 141–148.

23. Novotvary 2003. ÚZIS, Praha, 2006.

24. Ragin, CC, Taioli, E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer, 2007, 121(8), p. 1813–1820.

25. Rintala, MA., Grenman, SE., Puranen, MH., et al. Transmission of high-risk human papillomavirus (HPV) between parents and infant: a prospective study of HPV in families in Finland. J Clin Microbiol, 2005, 43, p. 376–381.

26. Rischin, D., Young, R., Fisher, R., et al. Prognostic significance of HPV and p16 status in patients with oropharyngeal cancer treated on a large international phase III trial (abstract). J Clin Oncol, 2009, 27 (Suppl. 15), Abstract 6004.

27. Schlecht, NF. Prognostic value of human papillomavirus in the survival of head and neck cancer patients: an overview of the evidence. Oncol Rep, 2005, 14, p. 1239–1247.

28. Schwartz, SM., Daling, JR., Doody, DR., et al. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst, 1998, 90, 1626–1636.

29. Shah, J. Head and neck surgery and oncology. Mosby 2004

30. Sinal, SH., Woods, CR. Human papilomavirus infections of the genital and respiratory tracts in young chidern. Sem Pediatr Infect Dis, 2005, 16, p. 306–316.

31. Smith, EM., Ritchie, JM., Summersgill, KF., et al. Age, se-xual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer, 2004, 108, p. 766–772.

32. Wilczynski, S., Lin, B., Xie, Y., Paz, B. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol, 1998, 152, p. 145–156.