Management of patient with breast carcinoma diagnosed during pregnancy

Česká verzia

Authors: M. Sládečková ¹; M. Bendová ¹; M. Kubecová ²; Martin Hruda ¹ ; Lukáš Rob ¹ ; Michael Jiří Halaška ¹
Authors place of work: Gynekologicko-porodnická klinika 3. LF UK a FN Královské Vinohrady, Praha, přednosta prof. MUDr. L. Rob, CSc. ¹; Radioterapeutická a onkologická klinika 3. LF UK a FN Královské Vinohrady, Praha, přednostka doc. MUDr. H. Malíková, Ph. D. ²
Published in the journal: Ceska Gynekol 2019; 84(4): 293-297
Category:

Summary

Objective: To present actual complex review of diagnosis and treatment of breast cancer during pregnancy, demonstrated on particular case report.

Design: Case report and review article.

Setting: University Hospital Královské Vinohrady, Prague Department of Obstetrics and Gynaecology, Department of Radiotherapy and Oncology.

Case report: Patient with breast cancer diagnosed in early pregnancy, her oncological treatment. Circumstantial finding was endometriosis of rectovaginal septum and dehiscence of uterotomy after C-section.

Discussion: On this case we demonstrate importance of all early diagnosis, prompt examination management and early therapy onset already during the pregnancy.

Conclusion: Breast cancer therapy results are equal in pregnant and non-pregnant women, when we compare patients of same age, with same stage and same biological characteristics of tumor. The obstacle during pregnancy is often late diagnosis, which causes bigger size of tumor and more extensive affection of lymphatics in time of therapy onset.

Keywords:

pregnancy – Endometriosis – breast cancer

Zdroje

1. Amant, F., Vanderbroucke, T., Verheecke, M., et al. Pediatric outcome afer maternal cancer diagnosed during pregnancy. New Engl J Med, 2015, 373, 19, p. 1824–1834.

2. Azim, HA Jr., Bellettini, G., Gelber, S., Peccatori, FA. Breast-feeding after breast cancer: if you wish, madam. Breast Cancer Res Treat, 2009, 1, p. 7–12.

3. Camune, B., Gabzdyl, E. Breast-feeding after breast cancer in childbearing women. J Perinat Neonatal Nurs, 2007, 3, p. 225–233.

4. de Haan, J., Verheecke, M., van Calsteren, K., et al. Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol, 2018, 19, p. 337.

5. Drochýtek, V., Rob, L., Halaška, MJ. Onkologická léčba v těhotenství. Onkologie, 2016, 10, 3, s. 135–137.

6. Eedarapalli, P., Jain, S. Breast cancer in pregnancy. J Obstet Gynaecol, 2006, 1, p. 1–4.

7. Eibye, S., Kjaer, SK., Mellemkjaer, L. Incidence of pregnancy-associated cancer in Denmark, 1977–2006. Am Obstet Gynecol, 2013, 122, 3, p. 608–617.

8. Halaška, MJ., Rob, L., Strnad, P., et al. Soubor pacientek s karcinomem prsu v souvislosti s těhotenstvím. Čes Gynek, 2007, 72, 3, s. 203–206.

9. Halaška, MJ., Rob, L., a kol. Onkologická onemocnění během těhotenství. Praha: Mladá fronta, 2015, s. 14–18.

10. Halaška, MJ., Komár, M., Vlk, R., et al. A pilot study on peak systolic velocity monitoring fetal anemia after administration of chemotherapy during pregnancy. Eur J Obstet Gynecol Reprod Biol, 2014, 174, p. 76–79.

11. Lee, YY., Roberts, CL., Dobbins, T., et al. Incidence and outcomes of pregancy-associated cancer in Australia, 1994–2008: a population-based linkage study. Intern J Obstet Gynaecol, 2012, 119, 13, p. 1572–1582.

12. Leslie, KK., Koil, C., Rayburn, WF. Chemotherapeutic drugs in pregnancy. Obstet Gynecol Clin North Am, 2005, 32, 4, p. 627–640.

13. Loibl, S., Han, SN., von Minckwitz, G., et al. Léčba karcinomu prsu během těhotenství: popisná studie. Lancet Oncol (české vyd.), 2013, 12, 1, s. 40–50.

14. Lyons, TR., Schedin, PJ., Borges, VF. Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia, 2009, p. 87–98.

15. Molckovsky, A., Madarnas, Y. Breast cancer in pregnancy: a literature review. Breast Cancer Res Treat, 2008, 3, p. 333–338.

16. Murthy, KR., Theriault, LR., Barnett, MCH., et al. Outcomes of children exposed in utero to chemotherapy for breast cancer. Breast Cancer Res, 2014, 16, 6, p. 500.

17. Pereg, D., Koren, G., Lishner, M. Cancer in pregnancy: gaps, challenges and solutions. Cancer Treatment Rev, 2008, 4, p. 302–312.

18. Sabate, JM., Clotet, M., Torrubia, S., et al. Radiologic evaluation of breast disorders related to pregnancy and lactation. Radiographics, 2007, Suppl. 1, p. 101–124.

19. Smith, LH., Danielsen, B., Allen, ME, Cress, R. Cancer associated with obstetric delivery: results of linkage with the California cancer registry. Amer J Obstet Gynecol, 2003, 189, 4, p. 1128–1135.

20. Škultéty, J., Halaška, MJ., Strnad, P., et al. Karcinom prsu v těhotenství. Prakt Gynekol, 2014, 18, 1, s. 42–46.