Treatment options for locally recurrent vulvar cancer

Česká verzia

Authors: Ndukwe M. ¹; Práznovec I. ¹; Štěpán M. ¹; Sirák I. ²; Fibír A. ³; Špaček J. ¹
Authors place of work: Porodnická a gynekologická klinika LF UK a FN Hradec Králové ¹; Klinika onkologie a radioterapie LF UK a FN Hradec Králové ²; Chirurgická klinika LF UK a FN Hradec Králové ³
Published in the journal: Ceska Gynekol 2021; 86(4): 246-248
Category: Case Report
doi: https://doi.org/10.48095/cccg2021246

Summary

Objective: Summarizing of treatment options for locally recurrent vulvar cancer in patients after previous complex oncological treatment and presenting a case report from our department. Methods: Presenting a case report of a patient after previous complex oncological treatment for spinocellular cancer of the vulva who presented with a locally recurrent tumor. The patient was treated with a wide radical local excision of the tumor followed by a posterior thigh flap graft. Conclusion: Surgical intervention is the primary mode of treatment in locally recurrent cancers of the vulva. Wide radical local excision as a mode of treatment can be optimized by the use of grafts aiding in wound healing.

Keywords:

recurrent vulvar cancer – wide radical local excision – graft transplant – brachytherapy – Chemotherapy – Chemoradiotherapy

Zdroje

1. Hacker NF, Eifel PJ, van der Velden J. Cancer of the vulva. Int J Gynaecol Obstet 2012; 119 (Suppl 2): S90–S96. doi: 10.1016/S0020-7292 (12) 60021-6.

2. Maggino T, Landoni F, Sartori E et al. Patterns of recurrence in patients with squamous cell carcinoma of the vulva. A multicenter CTF Study. Cancer 2000; 89 (1): 116–122. doi: 10.1002/1097-0142 (20000701) 89: 1<116:: aid-cncr16>3.0.co; 2-4.

3. De Hullu JA, Hollema H, Lolkema S et al. Vulvar carcinoma. The price of less radical surgery. Cancer 2002; 95 (11): 2331–2338. doi: 10.1002/cncr.10969.

4. Piura B, Masotina A, Murdoch J et al. Recurrent squamous cell carcinoma of the vulva: a study of 73 cases. Gynecol Oncol 1993; 48 (2): 189–195. doi: 10.1006/gyno.1993.1032.

5. Rouzier R, Haddad B, Plantier F et al. Local relapse in patients treated for squamous cell vulvar carcinoma: incidence and prognostic value. Obstet Gynecol 2002; 100 (6): 1159–1167. doi: 10.1016/s0029-7844 (02) 02501-2.

6. Woolderink JM, de Bock GH, de Hullu JA et al. Patterns and frequency of recurrences of squamous cell carcinoma of the vulva. Gynecol Oncol 2006; 103 (1): 293–299. doi: 10.1016/j.ygyno.2006.03.010.

7. Heaps JM, Fu YS, Montz FJ et al. Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990; 38 (3): 309–314. doi: 10.1016/0090-8258 (90) 90064-r.

8. Tilmans AS, Sutton GP, Look KY et al. Recurrent squamous carcinoma of the vulva. Am J Obstet Gynecol 1992; 167 (5): 1383–1389. doi: 10.1016/s0002-9378 (11) 91722-0.

9. Hopkins MP, Morley GW. Pelvic exenteration for the treatment of vulvar cancer. Cancer. 1992; 70 (12): 2835–2838. doi: 10.1002/1097-0142 (199212 15) 70: 12<2835:: aid-cncr2820701219>3.0.co; 2-u.

10. Miller B, Morris M, Levenback C et al. Pelvic exenteration for primary and recurrent vulvar cancer. Gynecol Oncol 1995; 58 (2): 202–205. doi: 10.1006/gyno.1995.1211.

11. Lee PK, Choi MS, Ahn ST et al. Gluteal fold V-Y advancement flap for vulvar and vaginal reconstruction: a new flap. Plast Reconstr Surg 2006; 118 (2): 401–406. doi: 10.1097/01.prs.0000227683.47836.28.

12. Weikel W, Hofmann M, Steiner E et al. Reconstructive surgery following resection of primary vulvar cancers. Gynecol Oncol 2005; 99 (1): 92–100. doi: 10.1016/j.ygyno.2005.05.031.

13. Gentileschi S, Servillo M, Garganese G et al. Surgical therapy of vulvar cancer: how to choose the correct reconstruction? J Gynecol Oncol 2016; 27 (6): e60. doi: 10.3802/jgo.2016.27.e60.

14. Tan BK, Kang GC, Tay EH et al. Subunit principle of vulvar reconstruction: algorithm and outcomes. Arch Plast Surg 2014; 41 (4): 379–386. doi: 10.5999/aps.2014.41.4.379.

15. Pirtoli L, Rottoli M. Results of radiation therapy for vulvar carcinoma. Acta Radiol Oncol 1982; 21 (1): 45–48. doi: 10.3109/02841868209133983.

16. Faul CM, Mirmow D, Huang Q et al. Adjuvant radiation for vulvar carcinoma: improved local control. Int J Radiat Oncol Biol Phys 1997; 38 (2): 381–389. doi: 10.1016/s0360-3016 (97) 82 500-x.

17. Buchler DA, Kline JC, Tunca JC et al. Treatment of recurrent carcinoma of the vulva. Gynecol Oncol 1979; 8 (2): 180–184. doi: 10.1016/0090-8258 (79) 90023-4.

18. Kellas-Ślęczka S, Białas B, Fijałkowski M et al. Interstitial high-dose-rate brachytherapy in locally advanced and recurrent vulvar cancer. J Contemp Brachytherapy 2016; 8 (1): 32–40. doi: 10.5114/jcb.2016.58081.

19. Cormio G, Loizzi V, Gissi F et al. Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma. Oncology 2009; 77 (5): 281–284. doi: 10.1159/000259259.

20. Singareddy R, Bajwa HK, Alluri KR et al. Carcinoma vulva patterns of recurrence and treatment outcomes: a single-institution experience. J Cancer Res Ther 2019; 15 (6): 1328–1331. doi: 10.4103/jcrt.JCRT_44_18.