Assisted reproduction in patients with Klinefelter syndrome

Česká verzia

Authors: K. Crha ¹ ; M Ješeta ¹ ; Radovan Pilka ² ; M. Kašík ³ ; L. Mekiňová ¹ ; J. Vodička ² ; Tomáš Crha ¹
Authors place of work: Gynekologicko-porodnická klinika LF MU a FN Brno ¹; Porodnicko-gynekologická klinika LF UP a FN Olomouc ²; Urologická klinika LF MU a FN Brno ³
Published in the journal: Ceska Gynekol 2022; 87(2): 133-136
Category: Review Article
doi: https://doi.org/10.48095/cccg2022133

Summary

Objective: The goal of this article is to present the current knowledge of Klinefelter syndrome and its impact on male reproductive function as well as the current treatment options. Methods: PubMed/Medline, WoS and Scopus were searched for articles indexed until November 2021. Text: Klinefelter syndrome is a chromosomal aberration with an additional X chromosome in males. This may adversely affect testicular growth and spermatogenesis, thus resulting in male infertility. Recently, new knowledge has appeared about the treatment of male infertility. Conclusion: Interdisciplinary approach enables early diagnosis and treatment of patients with Klinefelter syndrome. Assisted reproductive technology is essential for infertility treatment in patients with Klinefelter syndrome.

Keywords:

genetic testing – assisted reproduction – Aneuploidy – disorders of spermatogenesis – male sterility – Klinefelter syndrome

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