SARS-CoV-2 placentitis as a cause of intrauterine death of a fetus in a patient with covid-19 infection and ongoing HELLP syndrome
Authors:
Kouřilová J. 1; Hylmarová J. 2
Authors place of work:
Gynekologicko-porodnické oddělení, Nemocnice Znojmo p. o.
1; Ústav patologie, FN Brno
2
Published in the journal:
Ceska Gynekol 2022; 87(4): 269-273
Category:
Case Report
doi:
https://doi.org/10.48095/cccg2022269
Summary
Objective: We hereby present a case of intrauterine death of a fetus due to placental damage by placentitis caused by SARS-CoV-2 infection in ongoing covid-19 disease and HELLP syndrome. Case report: In this case report, we describe a patient who experienced intrauterine death of a fetus and the development of HELLP syndrome in ongoing covid-19 infection. Placentitis caused by SARS-CoV-2 infection was identified as the cause of intrauterine death of a fetus. After the end of pregnancy, a patient experienced an improvement in the symptoms of covid-19 and also a gradual improvement and adjustment of laboratory and coagulation parameters. Conclusion: SARS-CoV-2 infection in pregnancy can be complicated by the development of SARS-CoV-2 placenitis, which can cause intrauterine death of a fetus. Covid-19 infection can even have similar signs to HELLP syndrome and therefore careful monitoring of pregnant women with covid-19 is recommended.
Keywords:
HELLP syndrome – COVID-19 – pregnancy – placentitis
Zdroje
1. Mendoza M, Garcia-Ruiz I, Maiz N et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG 2020; 127 (11): 1374–1380. doi: 10.1111/1471-0528.16339.
2. Syeda S, Baptiste C, Breslin N et al. The clinical course of COVID in pregnancy. Semin Peri- natol 2020; 44 (7): 151284. doi: 10.1016/ j.semperi.2020.151284.
3. Daumová M, Hadravská Š, Straková Peteří- ková A. Morfologické nálezy v placentě asociované s infekcí SARS-CoV-2. Cesk Patol 2021; 57 (4): 199–202.
4. Watkins JC, Torous VF, Roberts DJ. Defining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) placentitis. Arch Pathol Lab Med 2021; 145 (11): 1341–1349. doi: 10.5858/ arpa.2021-0246-SA.
5. Schwartz DA, Baldewijns M, Benachi A et al. Chronic histiocytic intervillositis with trophoblast necrosis is a risk factor associated with placental infection from coronavirus disease 2019 (covid-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in live-born and stillborn infants. Arch Pathol Lab Med 2021; 145 (5): 517–528. doi: 10.5858/arpa.2020-0771-SA.
6. Dubucs C, Groussolles M, Ousselin J et al. Severe placental lesions due to maternal SARS-CoV-2 infection associated to intrauterine fetal death. Hum Pathol 2022; 121: 46–55. doi: 10.1016/ j.humpath.2021.12.012.
7. Gurol-Urganci I, Jardine JE, Carroll F et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol 2021; 225 (5): 522.e1–522.e11. doi: 10.1016/j.ajog.2021.05.016.
8. Válková A, Hubka P. Covid-19 jako rizikový faktor intrauterinního úmrtí plodu. Ceska Gynekol 2021; 86 (6): 410–413. doi: 10.48095/ cccg2021410.
9. Futterman I, Toaff M, Navi L et al. COVID-19 and HELLP: overlapping clinical pictures in two gravid patients. AJP Rep 2020; 10 (02): e179–e182. doi: 10.1055/s-0040-1712978.
10. Čivrná J, Skanderová D, Ehrmann J et al. HELLP syndrom a HELLP-like syndrom u těhotných s covid-19 – kazuistika. Ceska Gynekol 2021; 86 (4): 236–241. doi: 10.48095/cccg2021236.
11. Bubeníková Š, Cíchová A, Roubalová L et al. Využití poměru koncentrací solubilního receptoru tyrozinkinázového typu 1 a placentárního růstového faktoru pro krátkodobou predikci a diagnostiku preeklampsie. Ceska Gynekol 2016; 81 (4): 272–278.
Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineČlánok vyšiel v časopise
Czech Gynaecology
2022 Číslo 4
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