Anti-Müllerian hormone – clinical use and future possibilities

Česká verzia

Authors: O. Dubová ; Michal Zikán
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a FN Bulovka, Praha
Published in the journal: Ceska Gynekol 2023; 88(2): 126-130
Category: Review Article
doi: https://doi.org/10.48095/cccg2023126

Summary

Anti-Müllerian hormone (AMH) is a protein produced already in human fetus. It has an essential role in the differentiation of the reproductive tract, regulation of the ovaries and testes. The determination of serum AMH levels is used in clinical practice. Today, especially in reproductive medicine in the assessment of ovarian reserve and in the prediction of the response to ovarian stimulation. However, in young cancer patients, it can also predict the risk of ovarian failure after anticancer treatment. It finds further use in pediatric endocrinology in the diagnosis of sexual differentiation disorders. In oncology, it is used as a tumor marker for monitoring patients with granulosa tumors. In the future, however, it is also promising to use the knowledge of AMH function for the treatment of gynecological as well as other solid malignancies expressing a tissue-specific receptor for AMH.

Keywords:

endometrial cancer – ovarian cancer – BRCA – anti-Müllerian hormone – AMHRII – murlentamab

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