Anti-PM-Scl antibodies in myositis
Authors:
L. Pleštilová 1,2; J. Vencovský 1
Authors place of work:
Revmatologický ústav, Praha
1; 6. ročník, 3. lékařská fakulta, Univerzita Karlova, Praha
2
Published in the journal:
Čes. Revmatol., 17, 2009, No. 4, p. 200-204.
Category:
Overview Reports
Summary
Anti-PM-Scl antibodies are most frequently found in patients with overlap syndrome of polymyositis and systemic sclerosis (31%), less frequently in myositis alone (8–11%), or systemic sclerosis (2%). Detection of these antibodies is associated with better outcome of the disease, which usually responds well to the treatment with low- to medium-dose glucocorticoids. The “human exosome” is a PM-Scl autoantigen, a macromolecular complex of 11–16 polypeptides, which is involved in the degradation of precursor rRNA in the nucleolus and in the degradation of mature mRNA in the cytoplasm. Antibody response against the PM-Scl complex is primarily targeted against the PM-Scl-100 protein, the main epitope of which is PM1-α peptide.
Key words:
myositis, systemic sclerosis, exosome, anti-PM-Scl, PM1-α
Zdroje
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Štítky
Dermatology & STDs Paediatric rheumatology RheumatologyČlánok vyšiel v časopise
Czech Rheumatology
2009 Číslo 4
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