Lung involvement in connective tissue diseases
Authors:
M. Vašáková
Authors place of work:
Pneumologická klinika 1. LF UK, Fakultní Thomayerova nemocnice s poliklinikou
Published in the journal:
Čes. Revmatol., 18, 2010, No. 4, p. 192-200.
Category:
Overview Reports
Summary
Lung involvement in connective tissue diseases (CTDs) is relatively frequent and may present as diverse clinical-pathological manifestations. Using sensitive detection methods such as HRCT of lungs we may find lung involvement in as many as 70% with systemic sclerosis (SSc). In some CTDs the lung involvement is the leading cause of death and thus it should be actively looked for. Prognosis of different types of lung involvement in CTDs varies and depends on the proportion of inflammatory and fibrotic interstitial changes. Interstitial lung processes with prominent inflammation have usually better prognosis than those with extensive fibrotic changes. Treatment depends on the type of the autoimmune disease and on the phenotype of interstitial lung involvement and is usually based on steroids, immunosuppressive agents and targeted immunological, so-called biological, treatment.
Key words:
connective tissue diseases, lung involvement, prognosis, treatment
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Štítky
Dermatology & STDs Paediatric rheumatology RheumatologyČlánok vyšiel v časopise
Czech Rheumatology
2010 Číslo 4
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