Efficacy and safety of intra-articular injection of depot corticosteroids in rheumatic diseases
Authors:
R. Svobodová
Authors place of work:
Revmatologický ústav Praha
Published in the journal:
Čes. Revmatol., 23, 2015, No. 1, p. 22-32.
Category:
Rewiev
Summary
Glucocorticoids play a very important role in the treatment of rheumatic diseases. In order to control the disease activity it is sometimes necessary to use relatively high doses of systemically administered glucocorticoids, which are associated with a number of serious side effects. Intra-articular or peri-articular steroid injections help manage pain and inflammatory conditions in a short time, minimizing these side effects. This work provides a summary of available intra-articular glucocorticoids and the comparison of their pharmacokinetics, pharmacodynamics, efficacy and safety in various rheumatic diseases and introduces triamcinolone hexacetonide, a synthetic glucocorticoid with a prominent anti-inflammatory and depot effect.
Key words:
Glucocorticoids, intra-articular, triamcinolone hexacetonide, rheumatoid arthritis, osteoarthritis, juvenile idiopathic arthritis
Zdroje
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Štítky
Dermatology & STDs Paediatric rheumatology RheumatologyČlánok vyšiel v časopise
Czech Rheumatology
2015 Číslo 1
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